INT298887

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
neurite 1
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Congenital analgesia 3 90.80 High High
Nerve growth factor 3 88.60 High High
Pain 9 85.36 High High
Peripheral nervous system 3 66.40 Quite High
Demyelination 3 35.92 Quite Low
imagery 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 6 98.74 Very High Very High Very High
Pain 12 90.80 High High
Neurodegenerative Disease 12 84.12 Quite High
Charcot Marie Tooth Disease 18 63.84 Quite High
Mouth Disease 6 62.72 Quite High
Peripheral Neuropathy 3 58.00 Quite High
Disease 228 55.00 Quite High
Demyelinating Disease 3 35.92 Quite Low
Neurological Disease 6 32.40 Quite Low
Spinocerebellar Ataxia Type 2 3 26.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phenotypic similarity of CMT2B to these syndromes leads us to speculate that Rab7 mutations may cause premature degradation of TrkA-containing signaling endosomes with resulting attenuation of neurotrophic support and selective axonal degeneration in a length-dependent manner.
Protein_catabolism (degradation) of TrkA-containing associated with syndrome
1) Confidence 0.25 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.41 Pain Relevance 0.30
In cultured neurons, over-expression of dominant-negative Rab7 reduces the degradation of TrkA-containing signaling endosomes leading to increased trophic signaling and excessive neurite outgrowth (9).
Protein_catabolism (degradation) of TrkA-containing in neurite
2) Confidence 0.25 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.44 Pain Relevance 0.22
As such, Rab7 activity regulates the lysosome-mediated degradation of endocytic cargos such as activated EGF receptors, internalized cholesterol and neurotrophic factor receptors such as TrkA (6,9,10).
Protein_catabolism (degradation) of TrkA
3) Confidence 0.22 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox