INT298891

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.65
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (RAB7A) GTPase activity (RAB7A) lysosome (RAB7A)
RAB7A (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 25 85.20 High High
Pain 15 48.52 Quite Low
Demyelination 5 24.76 Low Low
Peripheral nervous system 5 10.00 Low Low
Congenital analgesia 5 5.00 Very Low Very Low Very Low
Nerve growth factor 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 380 99.96 Very High Very High Very High
Muscle Weakness 5 58.36 Quite High
Neuropathic Pain 5 55.88 Quite High
Amputation 5 51.88 Quite High
Congenital Anomalies 5 50.56 Quite High
Ulcers 5 50.04 Quite High
Pain 20 48.52 Quite Low
Mouth Disease 10 44.80 Quite Low
Charcot Marie Tooth Disease 30 44.24 Quite Low
Demyelinating Disease 5 24.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unregulated Rab7 cycling and accumulation of activated Rab7
Positive_regulation (accumulation) of Positive_regulation (activated) of Rab7
1) Confidence 0.47 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.48 Pain Relevance 0
We report that misregulation of Rab7 activation results in an increase in the active fraction of Rab7 and abnormal retention on target membranes.
Positive_regulation (results) of Positive_regulation (increase) of Rab7
2) Confidence 0.44 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.47 Pain Relevance 0
This finding indicates that accelerated GTP exchange in disease mutants leads to an increase in the active, GTP-bound fraction of Rab7.


Positive_regulation (leads) of Positive_regulation (increase) of Rab7 associated with disease
3) Confidence 0.44 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.45 Pain Relevance 0
Our results suggest increased activation of Rab7 disease mutants which would be predicted to correlate with alterations in the activity cycle.
Positive_regulation (increased) of Positive_regulation (activation) of Rab7 associated with disease
4) Confidence 0.44 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.68 Pain Relevance 0.07
We report that misregulation of Rab7 activation results in an increase in the active fraction of Rab7 and abnormal retention on target membranes.
Positive_regulation (results) of Positive_regulation (activation) of Rab7
5) Confidence 0.44 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.57 Pain Relevance 0

General Comments

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