INT298907

Context Info Confidence 0.86 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.22 Pain Relevance 0.03

mitochondrion (GFM1) intracellular (GFM1) GTPase activity (GFM1)

GFM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Peripheral nervous system 1 59.76 Demyelination 1 29.28 imagery 5 5.00 Pain 3 5.00 Congenital analgesia 1 5.00 Nerve growth factor 1 5.00

Disease Link Frequency Relevance Heat Charcot Marie Tooth Disease 6 57.20 Mouth Disease 2 56.08 Peripheral Neuropathy 1 51.36 Disease 76 50.00 Demyelinating Disease 1 29.28 Neurodegenerative Disease 4 5.00 Pain 4 5.00 Neurological Disease 2 5.00 Syndrome 2 5.00 Ulcers 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As such, Rab7 activity regulates the lysosome-mediated degradation of endocytic cargos such as activated EGF receptors, internalized cholesterol and neurotrophic factor receptors such as TrkA (6,9,10).

Protein_catabolism (degradation) of EGF

1) Confidence 0.86 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

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