INT298918

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RILP) lysosome (RILP)
RILP (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 7 30.44 Quite Low
chemokine 2 24.80 Low Low
Pain 7 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Congenital analgesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 101 91.92 High High
Gauchers Disease 86 70.16 Quite High
Conjunctivitis 1 37.20 Quite Low
Neurologic Manifestations 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low
Rare Diseases 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Charcot Marie Tooth Disease 6 5.00 Very Low Very Low Very Low
Aseptic Necrosis Of Bone 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GST-RILP showed increased interaction with the predominantly GTP-bound, GTPase-deficient Q67L mutant and no interaction with the GTP-binding deficient T22N mutant, indicating that this experiment accurately reflects changes in the active pool of Rab7 (Fig. 3D).
RILP Binding (interaction) of
1) Confidence 0.17 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.34 Pain Relevance 0
In the case of lysosomal enzymes, the chaperone concept involves the binding of the agent to the active site of the mutant lysosomal protein, thus stabilizing it for delivery to its normal site of action in the acidic environment of the organelle.
mutant lysosomal protein Binding (binding) of
2) Confidence 0.01 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.21 Pain Relevance 0

General Comments

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