INT298923

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 2 66.40 Quite High
Demyelination 2 35.92 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Congenital analgesia 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Charcot Marie Tooth Disease 12 63.84 Quite High
Mouth Disease 4 62.72 Quite High
Peripheral Neuropathy 2 58.00 Quite High
Disease 152 50.00 Quite Low
Demyelinating Disease 2 35.92 Quite Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such, Rab7 activity regulates the lysosome-mediated degradation of endocytic cargos such as activated EGF receptors, internalized cholesterol and neurotrophic factor receptors such as TrkA (6,9,10).
Positive_regulation (mediated) of Protein_catabolism (degradation) of TrkA
1) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.25 Pain Relevance 0.03
As such, Rab7 activity regulates the lysosome-mediated degradation of endocytic cargos such as activated EGF receptors, internalized cholesterol and neurotrophic factor receptors such as TrkA (6,9,10).
Positive_regulation (activated) of Protein_catabolism (degradation) of TrkA
2) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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