INT298979

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.75
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Traf6) protein complex (Traf6) ligase activity (Traf6)
cytoplasm (Traf6) signal transducer activity (Traf6) cytosol (Traf6)
Anatomy Link Frequency
monocytes 1
Traf6 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 67 99.12 Very High Very High Very High
cytokine 75 97.12 Very High Very High Very High
chemokine 8 96.08 Very High Very High Very High
tolerance 42 93.04 High High
Osteoarthritis 1 79.48 Quite High
agonist 22 74.56 Quite High
Inflammation 94 62.56 Quite High
Arthritis 64 61.52 Quite High
Inflammatory response 14 49.52 Quite Low
Central nervous system 68 48.08 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 9 100.00 Very High Very High Very High
Cancer 19 99.98 Very High Very High Very High
Rheumatoid Arthritis 67 99.12 Very High Very High Very High
Osteoarthritis 1 79.48 Quite High
Repression 1 75.60 Quite High
Arthritis 62 62.56 Quite High
INFLAMMATION 84 59.92 Quite High
Apoptosis 50 53.12 Quite High
Disease 120 50.00 Quite Low
Infection 16 49.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This event allows activation of the IL-1R-associated kinase (IRAK)/tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway leading to nuclear translocation of the nuclear factor kappa beta (NF-?
Gene_expression (necrosis) of TRAF6 associated with necrosis and cancer
1) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.20 Pain Relevance 0
This event allows activation of the IL-1R-associated kinase (IRAK)/tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway leading to nuclear translocation of the nuclear factor kappa beta (NF-?
Gene_expression (necrosis) of factor receptor-associated factor 6 associated with necrosis and cancer
2) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.20 Pain Relevance 0
Recent evidence indicates that TRIF associates with TRAF6 and induces NF-?
Gene_expression (with) of TRAF6
3) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.05 Pain Relevance 0.22
Interestingly, TRAF6, and IRAK-1, two targets of miR-146a [107] were produced at similar levels in RA and control monocytes, despite the finding of increased miR-146 expression by RA monocytes.
Gene_expression (produced) of TRAF6 in monocytes associated with rheumatoid arthritis
4) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.18 Pain Relevance 0.62
IRAK-M is a catalytically inactive member of the IRAK kinase family that prevents formation of IRAK-1–TRAF6 complexes downstream of TLR4 (15, 16).
Gene_expression (complexes) of TRAF6
5) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.12 Pain Relevance 0.37

General Comments

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