INT29898

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Context Info
Confidence 0.29
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.58
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)
Anatomy Link Frequency
B cell 4
plasma cells 1
lung 1
synovium 1
T lymphocytes 1
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 97.36 Very High Very High Very High
rheumatoid arthritis 268 97.24 Very High Very High Very High
abdominal pain 8 89.92 High High
abatacept 2 86.68 High High
antagonist 10 81.68 Quite High
Angina 4 78.96 Quite High
Inflammation 41 78.24 Quite High
Restless leg syndrome 1 74.96 Quite High
withdrawal 2 74.16 Quite High
methotrexate 40 60.40 Quite High
Disease Link Frequency Relevance Heat
Agammaglobulinemia 9 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 34 99.84 Very High Very High Very High
Infection 80 99.54 Very High Very High Very High
Exanthema 8 99.36 Very High Very High Very High
Toxicity 13 97.96 Very High Very High Very High
Bordatella Infection 2 97.68 Very High Very High Very High
Pain 8 97.36 Very High Very High Very High
Rheumatoid Arthritis 270 97.24 Very High Very High Very High
Fever 15 97.12 Very High Very High Very High
Lymphatic System Cancer 158 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasmapheresis carried out about 12 h after the end of ATG infusion resulted in a decrease in serum levels of total rabbit immunoglobulin as well as the antibody fraction reactive with human T lymphocytes.
Negative_regulation (decrease) of immunoglobulin in T lymphocytes
1) Confidence 0.29 Published 1988 Journal Transpl. Int. Section Abstract Doc Link 3075477 Disease Relevance 0.35 Pain Relevance 0.09
Further, we also showed that although conjugate vaccination resulted in increased pneumococcal capsule-specific immunoglobulin in lung fluid from both HIV infected and immunocompetent adults [24], the immunoglobulin function was impaired in HIV infected subjects [25].
Negative_regulation (impaired) of immunoglobulin in lung associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.13 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 1.11 Pain Relevance 0.04
Nine patients developed human anti-(mouse immunoglobulin) antibodies.
Negative_regulation (developed) of immunoglobulin
3) Confidence 0.09 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435869 Disease Relevance 0.45 Pain Relevance 0.10
However, only small decreases in immunoglobulin levels were seen, and mean immunoglobulin levels remained within normal limits throughout treatment [25].
Negative_regulation (decreases) of immunoglobulin
4) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833440 Disease Relevance 0.62 Pain Relevance 0.08
The laboratory findings of M-proteinemia (IgA 1215 mg/dl) with the decrease of other serum immunoglobulin level (IgG 611 mg/dl, IgM 60 mg/dl) and monoclonal IgA[symbol: see text]-type light chain in serum immunoelectrophoresis suggested MM four years ago.
Negative_regulation (decrease) of immunoglobulin associated with multiple myeloma
5) Confidence 0.05 Published 2000 Journal Ryumachi Section Abstract Doc Link 10783663 Disease Relevance 1.40 Pain Relevance 0.34
Similarly, surface immunoglobulin capping in B lymphocytes was also inhibited.
Negative_regulation (inhibited) of immunoglobulin in B lymphocytes
6) Confidence 0.04 Published 1988 Journal J. Cell. Physiol. Section Abstract Doc Link 2848043 Disease Relevance 0.26 Pain Relevance 0.07
The prevalance of selective immunoglobulin (Ig) A deficiency was 9.1%.
Negative_regulation (deficiency) of immunoglobulin
7) Confidence 0.02 Published 2009 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2768234 Disease Relevance 1.04 Pain Relevance 0.08
Immunoglobulin levels, particularly IgM and IgE, were reduced in some belimumab cohorts compared with placebo.
Negative_regulation (reduced) of Immunoglobulin
8) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.35 Pain Relevance 0.04
Reductions in anti-dsDNA or immunoglobulin levels compared with placebo were observed in some LymphoStat-B cohorts.
Negative_regulation (Reductions) of immunoglobulin
9) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833972 Disease Relevance 0.50 Pain Relevance 0
Toxicity was acceptable with no increase in infections in the rituximab maintenance group despite a prolonged reduction in immunoglobulin M and B cell levels.
Negative_regulation (reduction) of immunoglobulin M in B cell associated with toxicity and infection
10) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012428 Disease Relevance 0.57 Pain Relevance 0
It is probable that the lack of depletion of plasma cells with rituximab has avoided significant immunoglobulin deficiency in most clinical trials including rheumatoid patients (Edwards et al 2004; Moore et al 2004).
Negative_regulation (deficiency) of immunoglobulin in plasma cells associated with agammaglobulinemia
11) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.85 Pain Relevance 0.06
Another potential advantage is less infection due to the sparing of immunoglobulin deficiency, although a longer follow up will be required to confirm this observation.
Negative_regulation (deficiency) of immunoglobulin associated with agammaglobulinemia and infection
12) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.51 Pain Relevance 0.23
We suspect that focal transmission was associated with recent DENV introductions because of the 217 paired serologic specimens from positive cluster enrollees, only one revealed an elevated but declining immunoglobulin M level, which would be indicative of a recent DENV infection occurring up to 60 d prior to cluster initiation [22].
Negative_regulation (declining) of immunoglobulin M associated with infection
13) Confidence 0.01 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2577695 Disease Relevance 0.33 Pain Relevance 0
In the synovium, B cells and immunoglobulin constant region mRNA are significantly lowered in patients with a substantial (at or above American College of Rheumatology 50%) clinical response to rituximab [6].
Negative_regulation (lowered) of immunoglobulin in B cells
14) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.40 Pain Relevance 0.10
Primary lymphomas of the CNS (PCNSLs) show molecular features of the late germinal center exit B cell phenotype and are impaired in their terminal differentiation as indicated by a lack of immunoglobulin class switching.
Negative_regulation (lack) of immunoglobulin in B cell associated with lymphatic system cancer
15) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.45 Pain Relevance 0
In the synovium, B cells and immunoglobulin constant region mRNA are significantly lowered in patients with a substantial (at or above American College of Rheumatology 50%) clinical response to rituximab [6].
Negative_regulation (lowered) of immunoglobulin in synovium
16) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.40 Pain Relevance 0.10

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