INT298988

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 37 99.54 Very High Very High Very High
Inflammation 34 54.92 Quite High
Central nervous system 23 44.64 Quite Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
INFLAMMATION 38 54.92 Quite High
Hypertrophy 2 36.48 Quite Low
Neuroblastoma 2 7.20 Low Low
Systemic Lupus Erythematosus 61 5.00 Very Low Very Low Very Low
Disease 46 5.00 Very Low Very Low Very Low
Autoimmune Disease 24 5.00 Very Low Very Low Very Low
Multiple Sclerosis 16 5.00 Very Low Very Low Very Low
Stress 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B and subsequent production of proinflammatory cytokines while also inhibiting IRAK1 resulting in an increase in IFN-?
Positive_regulation (increase) of Gene_expression (resulting) of IRAK1 associated with cytokine
1) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.05 Pain Relevance 0.14
This event allows activation of the IL-1R-associated kinase (IRAK)/tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway leading to nuclear translocation of the nuclear factor kappa beta (NF-?
Positive_regulation (activation) of Gene_expression (necrosis) of IRAK associated with necrosis and cancer
2) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.20 Pain Relevance 0

General Comments

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