INT298998

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Il18, Cdk5) embryo development (Cdk5) cytosol (Cdk5)
extracellular space (Il18) cell death (Cdk5) nucleocytoplasmic transport (Cdk5)
Anatomy Link Frequency
neuron 1
Il18 (Mus musculus)
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 23 94.48 High High
Hippocampus 8 87.12 High High
cerebral cortex 1 84.08 Quite High
cytokine 23 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 99.72 Very High Very High Very High
Hypertrophy 2 84.68 Quite High
Stress 11 68.96 Quite High
Necrosis 1 52.48 Quite High
Cancer 2 52.12 Quite High
Disease 30 5.00 Very Low Very Low Very Low
INFLAMMATION 22 5.00 Very Low Very Low Very Low
Multiple Sclerosis 16 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, human neuron-like differentiated SH-SY5Y neuroblastomas exhibited an IL-18-dependent increase in the levels of several kinases including p35, Cdk5, GSK-3beta, and Ser15-phosphorylated p53 [50].


IL-18 Positive_regulation (increase) of Cdk5 in neuron associated with neuroblastoma
1) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.36 Pain Relevance 0.17

General Comments

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