INT299013

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
pyramidal neurons 1
Il18 (Mus musculus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 1 100.00 Very High Very High Very High
Pyramidal cell 1 99.06 Very High Very High Very High
nMDA receptor 1 82.68 Quite High
depression 7 80.28 Quite High
Glutamate receptor 1 75.84 Quite High
Hippocampus 8 57.16 Quite High
cytokine 23 34.56 Quite Low
Thalamus 1 23.92 Low Low
Substantia nigra 3 20.96 Low Low
Intracerebroventricular 1 16.40 Low Low
Disease Link Frequency Relevance Heat
Depression 7 80.28 Quite High
Anxiety Disorder 1 79.92 Quite High
Cognitive Disorder 6 69.72 Quite High
Stress 11 58.00 Quite High
Appetite Loss 2 50.92 Quite High
Insulin Resistance 1 42.24 Quite Low
Metabolic Syndrome 2 41.32 Quite Low
Fever 5 34.40 Quite Low
Disease 30 5.00 Very Low Very Low Very Low
INFLAMMATION 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Work on CA1 pyramidal neurons of mouse hippocampal slices demonstrated that IL-18 stimulated synaptically released glutamate and enhanced postsynaptic AMPA receptor responses, thereby facilitating basal hippocampal synaptic transmission without affecting LTP [76].
IL-18 Neg (without) Regulation (affecting) of LTP in pyramidal neurons associated with glutamate and pyramidal cell
1) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.39 Pain Relevance 0.25

General Comments

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