INT29905

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Context Info
Confidence 0.66
First Reported 1988
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ap2m1) mitochondrion (Ap2m1) vesicle-mediated transport (Ap2m1)
plasma membrane (Ap2m1)
Anatomy Link Frequency
neurons 1
pylorus 1
Ap2m1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 3 100.00 Very High Very High Very High
Opioid 2 98.80 Very High Very High Very High
Intracerebroventricular 1 97.64 Very High Very High Very High
Delta opioid receptors 2 95.76 Very High Very High Very High
MU agonist 2 89.52 High High
Enkephalin 3 85.04 High High
Substantia nigra 2 78.00 Quite High
opiate 2 75.00 Quite High
agonist 1 75.00 Quite High
antagonist 1 70.96 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies raise the possibility that both mu1 and mu2, but not delta, receptors are localized presynaptically on nigrostriatal neurons.
Localization (localized) of mu2 in neurons
1) Confidence 0.66 Published 1988 Journal Life Sci. Section Abstract Doc Link 2848168 Disease Relevance 0 Pain Relevance 0.39
Because the role of mu and delta opioid receptors in modulating gastric functions remains uncertain, we studied whether intracerebroventricular (i.c.v.) and subcutaneous (s.c.) injections of new opioid peptides with high selectivity for mu 1 (Lys7-dermorphin), mu 2 (Trp4-Asn7-dermorphin) and delta 2 (D-Ala2-deltorphin II) opioid receptors would modify gastric secretion (after 2 hr pylorus ligature) and transit (after a phenol red meal) in the rat.
Localization (secretion) of mu 2 in pylorus associated with opioid receptor, delta opioid receptors, opioid and intracerebroventricular
2) Confidence 0.53 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7845553 Disease Relevance 0 Pain Relevance 0.66

General Comments

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