INT299115

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.11
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INPP5K) endoplasmic reticulum (INPP5K) plasma membrane (INPP5K)
nucleus (INPP5K) cytoplasm (INPP5K)
Anatomy Link Frequency
domes 2
INPP5K (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 38 96.96 Very High Very High Very High
cINOD 4 91.44 High High
Spinal cord 4 85.92 High High
cytokine 4 75.84 Quite High
Inflammatory response 3 72.56 Quite High
Piles 8 60.52 Quite High
headache 3 46.68 Quite Low
Pain 16 27.92 Quite Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 41 100.00 Very High Very High Very High
Apoptosis 33 99.98 Very High Very High Very High
Infection 5 99.82 Very High Very High Very High
Inflammatory Bowel Disease 96 99.70 Very High Very High Very High
Frailty 23 98.56 Very High Very High Very High
Polio 30 98.04 Very High Very High Very High
Colon Disease 4 97.76 Very High Very High Very High
Disease 38 97.24 Very High Very High Very High
INFLAMMATION 37 96.96 Very High Very High Very High
Granuloma 4 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with mesalazine alone failed to improve the irregularity of the PPs’ domes and the surrounding villous atrophy despite the colonic disease achieving remission.
Regulation (irregularity) of PPs in domes associated with frailty and colon disease
1) Confidence 0.39 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.70 Pain Relevance 0.23
However, in 10 UC patients, the PPs’ domes were irregular and surrounded by atrophic villi that were sparse.
Regulation (irregular) of PPs in domes associated with inflammatory bowel disease
2) Confidence 0.39 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.64 Pain Relevance 0
Research has not been able to verify a persistent polio virus infection or relation to PPS, and it seems unlikely that persistent poliovirus infection plays a role in the pathogenesis of PPS.35–37
Regulation (role) of PPS associated with polio, syndrome and infection
3) Confidence 0.35 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.54 Pain Relevance 0.35
Effects of PPS on the deposition of collagen type II by MPCs in MMC as assessed by immunohistochemistry
Regulation (Effects) of PPS
4) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
To determine whether the increase in MPC number was related to the anti-apoptotic properties of PPS, MPC monolayer cultures were exposed to IL-4 and IFN?
Regulation (properties) of PPS associated with apoptosis
5) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.23 Pain Relevance 0
For the 7-day and 10-day culture periods, a progressive stimulation of collagen type II synthesis was observed with PPS concentrations up to 5 ?
Regulation (observed) of PPS
6) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0

General Comments

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