INT299153

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 8.14
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnc) extracellular space (Tnc) extracellular region (Tnc)
cell adhesion (Tnc) proteinaceous extracellular matrix (Tnc)
Anatomy Link Frequency
leukocyte 1
skin 1
Tnc (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 20 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
metalloproteinase 4 100.00 Very High Very High Very High
fibrosis 23 99.28 Very High Very High Very High
antiepileptic Drug 12 95.56 Very High Very High Very High
Lamotrigine 24 90.48 High High
carbamazepine 48 88.80 High High
Paracetamol 8 55.04 Quite High
corticosteroid 24 34.84 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Staphylococcus Infection 512 100.00 Very High Very High Very High
Bullous Skin Disease 424 100.00 Very High Very High Very High
Syndrome 20 100.00 Very High Very High Very High
INFLAMMATION 13 100.00 Very High Very High Very High
Skin Infection 4 100.00 Very High Very High Very High
Fibrosis 20 99.28 Very High Very High Very High
Acute Generalized Exanthematous Pustulosis 28 99.18 Very High Very High Very High
Disease 82 97.84 Very High Very High Very High
Hypersensitivity 12 96.40 Very High Very High Very High
Alopecia 4 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, the authors reported that no fibrosis-related biomarkers, such as tissue inhibitor of metalloproteinases-1 (TIMP-1), tenascin, osteopontin, or galectin-3, were reduced by MCS; only the loading-related biomarker BNP was reduced by MCS.
Negative_regulation (inhibitor) of tenascin associated with fibrosis and metalloproteinase
1) Confidence 0.42 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.71 Pain Relevance 0.22
Furthermore, studies in different populations indicate that the risk of developing SJS/TEN is highest when the drug has been recently initiated, and subsequently declines within 8 weeks or more of administration [5,55].
Negative_regulation (developing) of TEN associated with staphylococcus infection and bullous skin disease
2) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.47 Pain Relevance 0.46
Unfortunately the sensitivity of the LTT is still very low in SJS/TEN even if performed within one week after onset of the disease [108].
Negative_regulation (low) of TEN associated with staphylococcus infection, disease and bullous skin disease
3) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.66 Pain Relevance 0
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


Negative_regulation (necrolysis) of TEN in skin associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
4) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.91 Pain Relevance 0.15
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


Negative_regulation (ciclosporine) of TEN in leukocyte associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
5) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.40 Pain Relevance 0.15

General Comments

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