INT299176

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.36
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cysltr2) plasma membrane (Cysltr2) signal transducer activity (Cysltr2)
Anatomy Link Frequency
eosinophils 1
Cysltr2 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 78 99.12 Very High Very High Very High
antagonist 9 96.72 Very High Very High Very High
Inflammation 2 91.68 High High
withdrawal 2 54.44 Quite High
cINOD 2 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 2 98.20 Very High Very High Very High
Asthma 56 97.96 Very High Very High Very High
Rhinitis 5 92.20 High High
INFLAMMATION 3 91.68 High High
Hypersensitivity 11 90.24 High High
Obesity 4 67.96 Quite High
Bronchospasm 17 60.08 Quite High
Sinusitis 5 41.92 Quite Low
Occupational Lung Diseases 4 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eosinophils and mast cells show marked infiltration into the bronchial tree and nasal polyps in AIA and are important cell types in aspirin hypersensitivity of the airways.27,28 Endobronchial aspirin challenge induced a decrease in the number of mast cells that stained for tryptase and an increase in the number of activated eosinophils, which reflects degranulation of these cell types and an early event associated with aspirin-sensitive reactions in AIA subjects.29 Elevated levels of eotaxin and eotaxin-2 expression characterize tissue eosinophilia,30 and these levels are changed after aspirin challenge.31 In addition, both CYSLT1R and CYSLT2R are expressed on eosinophils, especially during exacerbation of asthma.32 Leukotriene receptor antagonists are effective in treating AIA, because they inhibit the production of leukotrienes and the degree of eosinophilic inflammation in the airways.33 Therefore, airway eosinophilia may be a critical marker for responsiveness.
Gene_expression (expressed) of CYSLT2R in eosinophils associated with asthma, aspirin, rhinitis, inflammation, antagonist, hypersensitivity and eosinophilia
1) Confidence 0.09 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 1.36 Pain Relevance 0.41

General Comments

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