INT299178

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cysltr1) cellular_component (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
nasal mucosa 1
Cysltr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 156 99.46 Very High Very High Very High
Potency 2 99.12 Very High Very High Very High
antagonist 18 83.60 Quite High
cINOD 4 70.96 Quite High
withdrawal 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 22 99.80 Very High Very High Very High
Asthma 112 98.84 Very High Very High Very High
Chronic Sinusitis 2 97.14 Very High Very High Very High
Occupational Lung Diseases 8 87.28 High High
Bronchospasm 34 71.40 Quite High
INFLAMMATION 6 70.40 Quite High
Rhinitis 10 5.00 Very Low Very Low Very Low
Sinusitis 10 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sousa et al. reported that the number of cells expressing CYSLTR1 in the nasal mucosa is significantly higher in cases of AIA with chronic rhinosinusitis than in aspirin-tolerant patients, suggesting that CYSLTR1 overexpression is crucial to the pathogenesis of aspirin hypersensitivity.4 CysLTs bind to CYSLTR1 with a rank order of potency of LTD4>LTC4>LTE4,24 and the receptor is antagonized selectively by currently available leukotriene modifiers, including MLK, pranlukast, and zafirlukast.8,9
CYSLTR1 Binding (bind) of in nasal mucosa associated with asthma, aspirin, chronic sinusitis, hypersensitivity and potency
1) Confidence 0.14 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 0.57 Pain Relevance 0.35
CysLTs exert their biological actions by binding to two types of G protein-coupled receptors, i.e., cysteinyl leukotriene receptor 1 (CYSLTR1), which is sensitive to the asthma drugs montelukast (MLK), zafirlukast, and pranlukast,8,9 and CYSLTR2.10
CYSLTR1 Binding (binding) of associated with asthma
2) Confidence 0.14 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 1.23 Pain Relevance 0.42

General Comments

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