INT299179

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cysltr1) cellular_component (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
nasal mucosa 2
Cysltr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 78 99.28 Very High Very High Very High
Potency 1 95.76 Very High Very High Very High
antagonist 9 76.88 Quite High
withdrawal 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Sinusitis 1 98.96 Very High Very High Very High
Asthma 56 98.40 Very High Very High Very High
Hypersensitivity 11 98.28 Very High Very High Very High
Bronchospasm 17 75.04 Quite High
Rhinitis 5 5.00 Very Low Very Low Very Low
Sinusitis 5 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 4 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sousa et al. reported that the number of cells expressing CYSLTR1 in the nasal mucosa is significantly higher in cases of AIA with chronic rhinosinusitis than in aspirin-tolerant patients, suggesting that CYSLTR1 overexpression is crucial to the pathogenesis of aspirin hypersensitivity.4 CysLTs bind to CYSLTR1 with a rank order of potency of LTD4>LTC4>LTE4,24 and the receptor is antagonized selectively by currently available leukotriene modifiers, including MLK, pranlukast, and zafirlukast.8,9
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYSLTR1 in nasal mucosa associated with asthma, aspirin, chronic sinusitis, hypersensitivity and potency
1) Confidence 0.18 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 0.51 Pain Relevance 0.29

General Comments

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