INT299196

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thy1) endoplasmic reticulum (Thy1) plasma membrane (Thy1)
enzyme binding (Thy1) cytoskeleton organization (Thy1)
Anatomy Link Frequency
optic nerve 1
Thy1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 20 49.32 Quite Low
anesthesia 5 36.52 Quite Low
potassium channel 5 23.28 Low Low
hyperexcitability 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 20 99.22 Very High Very High Very High
Ganglion Cysts 45 98.96 Very High Very High Very High
Hypertrophy 5 92.24 High High
Glaucoma 55 88.08 High High
Injury 85 86.04 High High
Low Tension Glaucoma 5 85.12 High High
Nerve Degeneration 5 81.52 Quite High
Optic Nerve Injuries 35 75.28 Quite High
Head Trauma 10 71.68 Quite High
Ocular Hypertension 25 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time analyses of AQP4/AQP9/Kir4.1/thy-1/ACTB mRNA levels
Transcription (levels) of thy-1
1) Confidence 0.66 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0 Pain Relevance 0
For example, while the RGC population decreased by approximately 47% at day 7, thy-1 mRNA decreased by 94%, showing that the reduction of thy-1 mRNA is much greater than the loss of RGCs.


Transcription (reduction) of thy-1
2) Confidence 0.55 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.41 Pain Relevance 0
Thy-1 mRNA at 2 weeks was below detection levels.
Transcription (was) of Thy-1
3) Confidence 0.55 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.31 Pain Relevance 0
Reduction of rat retinal ganglion cells after optic nerve crush and correlation with thy-1 mRNA and protein levels
Transcription (levels) of thy-1 in optic nerve associated with ganglion cysts
4) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.17 Pain Relevance 0
Our results are in agreement with earlier reports showing that thy-1 is an early marker of RGC stress but not a marker of RGC loss and that thy-1 mRNA and protein levels do not reflect the number of RGCs present in models of retinal damage [81-83].
Transcription (levels) of thy-1 associated with stress
5) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 1.09 Pain Relevance 0

General Comments

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