INT299215

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.94
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnj1)
Anatomy Link Frequency
retina 2
plexiform layer 1
B cell 1
Kcnj1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 5 98.68 Very High Very High Very High
ischemia 20 5.00 Very Low Very Low Very Low
hyperexcitability 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
B-cell Lymphoma 10 100.00 Very High Very High Very High
Apoptosis 15 98.48 Very High Very High Very High
Injury 85 93.40 High High
Ganglion Cysts 45 88.12 High High
Nervous System Injury 5 86.84 High High
Glaucoma 55 83.32 Quite High
Death 10 81.68 Quite High
Optic Nerve Injuries 35 77.12 Quite High
Disease 10 76.16 Quite High
Low Tension Glaucoma 5 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Müller cells, AQP4 co-localizes with an important retinal potassium channel known as Kir4.1 (mediates bidirectional K+ currents), and the co-expression of AQP4 with Kir4.1 suggests that water transport is coupled to the spatial buffering K+ currents [45,46].
Gene_expression (expression) of Kir4.1 associated with potassium channel
1) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.26 Pain Relevance 0.05
Therefore, the effect of optic nerve crush on Kir4.1 expression in retina was tested.
Gene_expression (expression) of Kir4.1 in retina
2) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.16 Pain Relevance 0.04
However, AQP4 is expressed alone in the plexiform layer, whereas Kir4.1 is not.
Gene_expression (is) of Kir4.1 in plexiform layer
3) Confidence 0.07 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.65 Pain Relevance 0
The reduced expression of AQP4 and Kir4.1 suggests dysfunctional ion coupling in retina following ONC and likely impaired retinal function.
Gene_expression (expression) of Kir4.1 in retina
4) Confidence 0.06 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.43 Pain Relevance 0
Changes in AQP4, AQP9, Kir4.1, B cell lymphoma-x (bcl-xl), and glial fibrillary acidic protein (GFAP) expression were measured in total retinal extracts using western blotting.


Gene_expression (expression) of Kir4.1 in B cell associated with b-cell lymphoma
5) Confidence 0.06 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.44 Pain Relevance 0

General Comments

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