INT299223

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
retina 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 12 95.84 Very High Very High Very High
hyperexcitability 2 93.32 High High
ischemia 11 84.56 Quite High
anesthesia 4 37.20 Quite Low
imagery 24 32.88 Quite Low
Versed 3 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 38 99.56 Very High Very High Very High
Intracranial Hypertension 7 95.84 Very High Very High Very High
Hydrocephalus 43 91.76 High High
Cv Unclassified Under Development 7 84.56 Quite High
Middle Cerebral Artery Infarction 4 80.00 Quite High
Stroke 4 73.36 Quite High
Neurologic Manifestations 2 64.80 Quite High
Stress 8 46.96 Quite Low
Hypoxia 10 39.36 Quite Low
Nervous System Injury 2 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the acute decreased abundance of AQP4 in the periventricular region we found normal ADC-values in the same region.
Negative_regulation (decreased) of Transcription (abundance) of AQP4
1) Confidence 0.59 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.83 Pain Relevance 0.26
In the present study using the rat ONC model, we have shown for the first time that such injury causes a significant decrease in AQP4 and Kir4.1 protein and mRNA levels in retina, suggesting impaired ion homeostasis and K+ spatial buffering.
Negative_regulation (decrease) of Transcription (levels) of AQP4 in retina associated with injury
2) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.54 Pain Relevance 0.09
Real-time analyses of AQP4/AQP9/Kir4.1/thy-1/ACTB mRNA levels
Negative_regulation (/) of Transcription (levels) of AQP4
3) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0 Pain Relevance 0

General Comments

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