INT299223

Context Info Confidence 0.59 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.36 Pain Relevance 0.35

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4) cytoplasm (Aqp4)

Anatomy Link Frequency retina 2 Aqp4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cva 12 95.84 hyperexcitability 2 93.32 ischemia 11 84.56 anesthesia 4 37.20 imagery 24 32.88 Versed 3 5.00 potassium channel 2 5.00 Central nervous system 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Injury 38 99.56 Intracranial Hypertension 7 95.84 Hydrocephalus 43 91.76 Cv Unclassified Under Development 7 84.56 Middle Cerebral Artery Infarction 4 80.00 Stroke 4 73.36 Neurologic Manifestations 2 64.80 Stress 8 46.96 Hypoxia 10 39.36 Nervous System Injury 2 30.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Together with the acute decreased abundance of AQP4 in the periventricular region we found normal ADC-values in the same region.

Negative_regulation (decreased) of Transcription (abundance) of AQP4

1) Confidence 0.59 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.83 Pain Relevance 0.26

In the present study using the rat ONC model, we have shown for the first time that such injury causes a significant decrease in AQP4 and Kir4.1 protein and mRNA levels in retina, suggesting impaired ion homeostasis and K+ spatial buffering.

Negative_regulation (decrease) of Transcription (levels) of AQP4 in retina associated with injury

2) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.54 Pain Relevance 0.09

Real-time analyses of AQP4/AQP9/Kir4.1/thy-1/ACTB mRNA levels

Negative_regulation (/) of Transcription (levels) of AQP4

3) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0 Pain Relevance 0

General Comments

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