INT299263

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PTPN3, VEGFA, SRC) cytoskeleton (PTPN3, SRC) plasma membrane (PTPN3, SRC)
mitochondrion (SRC) cytosol (SRC) cytoskeletal protein binding (PTPN3)
PTPN3 (Homo sapiens)
VEGFA (Homo sapiens)
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 5 99.68 Very High Very High Very High
opiate 9 82.00 Quite High
palliative 2 77.52 Quite High
Opioid 5 73.16 Quite High
antagonist 10 66.44 Quite High
narcan 1 40.40 Quite Low
Pain management 1 22.24 Low Low
analgesia 2 20.08 Low Low
Breakthrough pain 1 18.24 Low Low
Morphine 3 15.76 Low Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 76.12 Quite High
Cancer 6 75.88 Quite High
Constipation 1 74.00 Quite High
Disease 2 61.92 Quite High
Pain 2 22.24 Low Low
Renal Cancer 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Thrombocytopenia 1 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 1 5.00 Very Low Very Low Very Low
Asthenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
tyrosine phosphatase Negative_regulation (inhibits) of VEGF-induced Positive_regulation (activation) of Src associated with mu opioid receptor
1) Confidence 0.03 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.57

General Comments

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