INT299286

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VEGFA, PI3) proteinaceous extracellular matrix (VEGFA, PI3) extracellular space (VEGFA)
growth (VEGFA) cytoplasm (VEGFA)
VEGFA (Homo sapiens)
PI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 10 98.78 Very High Very High Very High
opiate 18 80.20 Quite High
palliative 4 75.72 Quite High
Opioid 10 71.36 Quite High
antagonist 20 64.64 Quite High
narcan 2 42.16 Quite Low
Pain management 2 24.00 Low Low
analgesia 4 21.84 Low Low
Breakthrough pain 2 20.00 Low Low
Morphine 6 13.96 Low Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 74.32 Quite High
Cancer 12 74.08 Quite High
Constipation 2 72.20 Quite High
Disease 4 63.68 Quite High
Renal Cancer 4 56.88 Quite High
Hyperinsulinism 2 42.88 Quite Low
Pain 4 24.00 Low Low
Anaemia 2 5.00 Very Low Very Low Very Low
Thrombocytopenia 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
VEGF-induced Positive_regulation (activation) of PI3 associated with mu opioid receptor
1) Confidence 0.16 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.34 Pain Relevance 0.55
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
VEGF-induced Positive_regulation (activation) of PI3 associated with mu opioid receptor
2) Confidence 0.16 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.11 Pain Relevance 0.05

General Comments

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