INT29929

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 5.81
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) DNA binding (Rb1)
cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
stroma 4
uterus 1
oocytes 1
motor neurons 1
placenta 1
Rb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 2 99.96 Very High Very High Very High
Calcitonin gene-related peptide 10 99.50 Very High Very High Very High
agonist 113 99.16 Very High Very High Very High
Pain 13 99.16 Very High Very High Very High
substance P 14 99.04 Very High Very High Very High
Antinociceptive 6 97.60 Very High Very High Very High
Dopamine 1 96.56 Very High Very High Very High
Nicotine 10 94.96 High High
Paracetamol 4 94.52 High High
tail-flick 2 86.96 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 80 100.00 Very High Very High Very High
Glioma 96 98.74 Very High Very High Very High
Nociception 8 98.60 Very High Very High Very High
Pain 9 98.24 Very High Very High Very High
Apoptosis 52 98.12 Very High Very High Very High
Cancer 174 97.68 Very High Very High Very High
Malaria 57 97.28 Very High Very High Very High
Infection 159 92.18 High High
Death 1 83.80 Quite High
Colon Cancer 7 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The placenta was negative for both PRAB and PRB.
Neg (negative) Gene_expression (negative) of PRB in placenta
1) Confidence 0.69 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.14 Pain Relevance 0
In the uterine stroma of the early pregnant rats PRAB immunostaining was strong, while PRB was very faintly expressed.
Gene_expression (expressed) of PRB in stroma
2) Confidence 0.69 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.15 Pain Relevance 0
Monoclonal mouse anti-human antibodies were used for detection of PRAB (MA1-410, Affinity Bioreagents Inc.) and PRB (MA1-411, Affinity Bioreagents Inc.).
Gene_expression (detection) of PRB
3) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
The amount of PCR products for PRAB, PRB and RPLP0 increased linearly up to 24, 25 and 21 cycles, respectively.
Gene_expression (products) of PRB
4) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
Further evaluation of 5-bromonicotine indicated that it might be a partial agonist at alpha4beta2 receptors (stimulation of Rb(+) efflux; alpha4beta2 receptors expressed in oocytes) and at alpha3-containing nicotinic acetylcholine receptors (synaptosomal dopamine release).
Gene_expression (expressed) of Rb in oocytes associated with dopamine and agonist
5) Confidence 0.56 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11821023 Disease Relevance 0 Pain Relevance 0.74
From the experiment with E2 and/or P treatment only stroma seems to express PRA in cells not expressing PRB, since in this compartment differences between PRAB and PRB immunostaining are apparent.
Neg (not) Gene_expression (expressing) of PRB in stroma
6) Confidence 0.53 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.11 Pain Relevance 0
Since PRA is basically impossible to detect by immunohistochemistry, we have used one antibody which detect only PRB and one that binds both PRA and PRB.
Gene_expression (detect) of PRB
7) Confidence 0.53 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.06
The selective expression of PRB in the uterus (PRA knock-outs) results in some PRB dependent proliferative activity, indicating that PRA is required to adverse some proliferative effects of the PRB protein [24].
Gene_expression (expression) of PRB in uterus associated with targeted disruption
8) Confidence 0.53 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.28 Pain Relevance 0
The uterine stroma of pregnant rats strongly expressed PRAB, but very little PRB, which is different to E2 treated ovx animals where both PRAB and PRB are strongly expressed.
Gene_expression (expressed) of PRB in stroma
9) Confidence 0.53 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.18
In the absence of PRB, AG formation in rat hepatic S9 fractions was saturable (V(max) = 2.77 +/- 0.36 nmol/ min/mg protein; K(M) = 18.0 +/- 0.92 mM).
Neg (absence) Gene_expression (absence) of PRB
10) Confidence 0.52 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9311615 Disease Relevance 0 Pain Relevance 0.25
This is in agreement with the results from PRAB knock-out mice, where no implantation and no decidual stimulation were obtained [22], while PRB knock-outs (i.e.
Gene_expression (knock) of PRB associated with targeted disruption
11) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.20 Pain Relevance 0
The uterine stroma of pregnant rats strongly expressed PRAB, but very little PRB, which is different to E2 treated ovx animals where both PRAB and PRB are strongly expressed.
Gene_expression (expressed) of PRB in stroma
12) Confidence 0.46 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.18
Furthermore, Rb1, Rb2, Rd, or Rf treated spinally produce antinociception in the substance P-induced pain model.
Gene_expression (produce) of Rb1 associated with pain, antinociception and substance p
13) Confidence 0.30 Published 2003 Journal Planta Med. Section Abstract Doc Link 14735436 Disease Relevance 0.50 Pain Relevance 0.76
CGRP receptor binding sites (RB) are found in many of the sites where IR axons terminate and in some cases, e.g. motor neurons, which express intraneuronal IR.
Gene_expression (found) of RB in motor neurons associated with calcitonin gene-related peptide
14) Confidence 0.29 Published 1988 Journal Brain Res. Section Abstract Doc Link 2848610 Disease Relevance 0 Pain Relevance 0.37
Among the several ginsenosides studied, Rb2, Rc, Rd, and Re, but not Rb1, Rf, Rg1 and Rg3, treated i.c.v. (50 microg) attenuated the nociceptive behavior induced by substance P injected i.t.
Gene_expression (treated) of Rb1 associated with nociception and substance p
15) Confidence 0.26 Published 2003 Journal Planta Med. Section Abstract Doc Link 14735436 Disease Relevance 0.42 Pain Relevance 0.43
Sulindac and sulindac sulfide decrease the levels of mitotic cyclins, induce the levels of p21WAF-1/cip1, and reduce the total levels of pRB, with a relative increase in the amount of the underphosphorylated form of pRB in a time- and concentration-dependent manner.
Gene_expression (levels) of pRB
16) Confidence 0.17 Published 1996 Journal Oncogene Section Abstract Doc Link 8632912 Disease Relevance 0.81 Pain Relevance 0.07
Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression

Background

Gene_expression (expression) of pRb associated with cancer and glioma
17) Confidence 0.10 Published 2009 Journal Lipids Health Dis Section Title Doc Link PMC2661078 Disease Relevance 0.71 Pain Relevance 0.03
GLA was found to alter the expression of several proteins involved in cell cycle control (Figure 3). pRb protein expression was decreased (62 ± 18%) while E2F1 remained unchanged (Figure 3A, 3B).
Gene_expression (expression) of pRb
18) Confidence 0.10 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.53 Pain Relevance 0
Increased p53 expression together with these changes in pRb and cyclin D1 can significantly increase cell apoptosis [37-39].
Gene_expression (expression) of pRb associated with apoptosis
19) Confidence 0.05 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.93 Pain Relevance 0
These effects involve changes in protein expression of VEGF, Flt1, ERK1, ERK2, MMP2, Cyclin D1, pRb, p53 and p27.
Gene_expression (expression) of pRb
20) Confidence 0.05 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.33 Pain Relevance 0.03

General Comments

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