INT299319

Context Info Confidence 0.44 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0.09

isomerase activity (FKBP1A) protein folding (FKBP1A) cytosol (FKBP1A) signal transduction (FKBP1A) cytoplasm (FKBP1A) signal transducer activity (FKBP1A)

FKBP1A (Homo sapiens)

Pain Link Frequency Relevance Heat Immobilon 6 88.52 antagonist 30 29.28 Opioid 15 28.84 opiate 27 5.00 mu opioid receptor 15 5.00 Morphine 9 5.00 palliative 6 5.00 analgesia 6 5.00 narcan 3 5.00 Pain management 3 5.00

Disease Link Frequency Relevance Heat Cancer 18 5.00 Renal Cancer 6 5.00 Pain 6 5.00 Disease 6 5.00 Anaemia 3 5.00 Thrombocytopenia 3 5.00 Hepatocellular Cancer 3 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Asthenia 3 5.00 Mucositis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The siRNA for human mTOR, Src, Rictor, FKBP12 and Akt were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and were utilized according to the manufacturer's specifications.

Localization (utilized) of FKBP12

1) Confidence 0.44 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.04

To further investigate the roles of MNTX and temsirolimus in VEGF-mediated Akt signaling, we examined two main mTOR-associated protein complexes, mTOR Complex 1, consisting of various proteins including mTOR, FKBP12 (a major target of mTOR inhibitors including temsirolimus) and Raptor, and mTOR Complex 2, consisting of various proteins including SIN1 and Rictor.

Localization (target) of FKBP12

2) Confidence 0.44 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0

The siRNA for human mTOR, Src, Rictor, FKBP12 and Akt were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and were utilized according to the manufacturer's specifications.

Localization (purchased) of FKBP12

3) Confidence 0.44 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.