INT299331

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.90
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPTOR) lysosome (RPTOR) cytoplasm (RPTOR)
RPTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 30 97.56 Very High Very High Very High
opiate 54 77.76 Quite High
palliative 12 73.28 Quite High
Opioid 30 68.92 Quite High
antagonist 60 62.20 Quite High
Morphine 18 58.32 Quite High
analgesia 12 56.44 Quite High
narcan 6 52.64 Quite High
Breakthrough pain 6 37.56 Quite Low
Pain management 6 35.48 Quite Low
Disease Link Frequency Relevance Heat
Disease 12 74.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 71.88 Quite High
Cancer 36 71.64 Quite High
Constipation 6 69.76 Quite High
Renal Cancer 12 54.44 Quite High
Hyperinsulinism 6 40.44 Quite Low
Pain 12 37.56 Quite Low
Anaemia 6 5.00 Very Low Very Low Very Low
Thrombocytopenia 6 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated mTOR Complex 1 phosphorylates several target proteins including S6K and 4EBP1 involved in cell proliferation, growth and survival [1,2,4,5,26].
Positive_regulation (Activated) of mTOR
1) Confidence 0.63 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.28
We inhibited PI3 kinase activity with LY294002 or silenced (siRNA) Src or Rictor (required for mTOR Complex 2 formation), challenged EC with VEGF and examined Akt activation.
Positive_regulation (required) of mTOR
2) Confidence 0.46 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
Temsirolimus and rapamycin inhibit the downstream target of activated Akt, mTOR Complex 1.
Positive_regulation (activated) of mTOR
3) Confidence 0.42 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.10 Pain Relevance 0.05
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
Positive_regulation (activation) of mTOR associated with mu opioid receptor
4) Confidence 0.42 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.11 Pain Relevance 0.05
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
Positive_regulation (activation) of mTOR associated with mu opioid receptor
5) Confidence 0.42 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.59
Temsirolimus and rapamycin inhibit the downstream target of activated Akt, mTOR Complex 1 [1,15,26].
Positive_regulation (activated) of mTOR
6) Confidence 0.37 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.67

General Comments

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