INT299333

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.25
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPTOR) lysosome (RPTOR) cytoplasm (RPTOR)
RPTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 80 93.24 High High
Opioid 40 92.80 High High
Immobilon 16 92.64 High High
opiate 72 90.00 High High
mu opioid receptor 40 88.72 High High
palliative 16 85.52 High High
MU agonist 8 41.64 Quite Low
Morphine 24 23.76 Low Low
narcan 8 20.64 Low Low
analgesia 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 84.12 Quite High
Cancer 48 83.88 Quite High
Constipation 8 82.00 Quite High
Disease 16 42.16 Quite Low
Appetite Loss 8 34.60 Quite Low
Thrombocytopenia 8 33.48 Quite Low
Hyperglycemia 8 32.76 Quite Low
Anaemia 8 32.16 Quite Low
Pressure And Volume Under Development 8 31.84 Quite Low
Vomiting 8 31.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that the synergistic effects of MNTX with mTOR inhibitors are achieved through inhibition of different components of a common VEGF-induced angiogenic signaling pathway.
Gene_expression (effects) of mTOR
1) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.25 Pain Relevance 0.62
The roles of mTOR Complex components, Akt and Src in MNTX and temsirolimus inhibition of VEGF-induced angiogenesis
Gene_expression (components) of mTOR
2) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.14
Specifically, mTOR exists in a rapamycin-sensitive complex (mTOR Complex 1) with the regulatory-associated protein of mTOR (Raptor) and a rapamycin-insensitive complex (mTOR Complex 2) with the rapamycin-insensitive companion of mTOR, Rictor [1-5,13,15].
Gene_expression (exists) of mTOR
3) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.10
Interestingly, the mTOR inhibitor, temsirolimus, did not attenuate Akt activation but inhibited the mTOR Complex 1 target p70 S6K [4] (Figure 4-B).
Gene_expression (target) of mTOR
4) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
Transfection of siRNA against mTOR, Src, Rictor, FKBP12 and Akt
Gene_expression (Transfection) of mTOR
5) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.05
MNTX-induced Src inactivation results in inhibition of PI3 kinase and mTOR signaling required for Akt activation (serine/threonine phosphorylation).
Gene_expression (kinase) of mTOR
6) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.08
Specifically, mTOR exists in a rapamycin-sensitive complex (mTOR Complex 1) with the regulatory-associated protein of mTOR (Raptor) and a rapamycin-insensitive complex (mTOR Complex 2) with the rapamycin-insensitive companion of mTOR, Rictor [1-5,13,15].
Gene_expression (exists) of mTOR
7) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.10
Specifically, mTOR exists in a rapamycin-sensitive complex (mTOR Complex 1) with the regulatory-associated protein of mTOR (Raptor) and a rapamycin-insensitive complex (mTOR Complex 2) with the rapamycin-insensitive companion of mTOR, Rictor [1-5,13,15].
Gene_expression (exists) of Raptor
8) Confidence 0.53 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.10

General Comments

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