INT299338

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.32
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 5 92.44 High High
opiate 9 75.08 Quite High
palliative 3 70.60 Quite High
Opioid 5 66.24 Quite High
antagonist 10 59.52 Quite High
narcan 1 52.16 Quite High
Pain management 1 34.00 Quite Low
analgesia 2 31.84 Quite Low
Breakthrough pain 1 30.00 Quite Low
Morphine 3 8.84 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 4 97.36 Very High Very High Very High
Skin Cancer 62 95.96 Very High Very High Very High
Cancer 62 93.00 High High
Monosomy 20 84.84 Quite High
Melanoma 91 81.72 Quite High
Aneuploidy 2 76.88 Quite High
Chromosome Aberrations 10 76.08 Quite High
Disease 6 73.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 69.20 Quite High
Constipation 1 67.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTEN is thought to be inactivated by deletion or mutation and through loss of its negative regulatory effect on AKT, lead to activation of the AKT-pathway, and consequently prevent apoptosis [85, 111].
Negative_regulation (loss) of Regulation (effect) of AKT associated with apoptosis
1) Confidence 0.31 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.98 Pain Relevance 0
Temsirolimus and rapamycin inhibit the downstream target of activated Akt, mTOR Complex 1 [1,15,26].
Negative_regulation (inhibit) of Regulation (target) of Akt
2) Confidence 0.28 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.68

General Comments

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