INT299341

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPTOR) lysosome (RPTOR) cytoplasm (RPTOR)
RPTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 20 64.76 Quite High
mu opioid receptor 10 64.08 Quite High
Morphine 6 8.00 Low Low
opiate 18 5.00 Very Low Very Low Very Low
Opioid 10 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
narcan 2 5.00 Very Low Very Low Very Low
Pain management 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 12 52.48 Quite High
Renal Cancer 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Anaemia 2 5.00 Very Low Very Low Very Low
Thrombocytopenia 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 5.00 Very Low Very Low Very Low
Asthenia 2 5.00 Very Low Very Low Very Low
Mucositis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results (Figure 5-B) indicate that Src is required for both serine and threonine phosphorylation of Akt, the PI3 kinase pathway is required for threonine phosphorylation of Akt and mTOR Complex 2 is required for serine phosphorylation of Akt.
Positive_regulation (required) of Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.46 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
Inhibition of tyrosine phosphatase activity (3,4-dephostatin) blocked the synergy between MNTX and temsirolimus and increased VEGF-induced tyrosine phosphorylation of Src with enhanced PI3 kinase and mTOR Complex 2-dependent phosphorylation of Akt and subsequent activation of mTOR Complex 1 (rapamycin and temsirolimus target), while silencing Src, Akt or mTOR complex 2 components blocked VEGF-induced angiogenic events.


Positive_regulation (dependent) of Phosphorylation (phosphorylation) of mTOR
2) Confidence 0.42 Published 2010 Journal J Angiogenes Res Section Abstract Doc Link PMC2831839 Disease Relevance 0.10 Pain Relevance 0.06

General Comments

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