INT299342

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.06
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPTOR) lysosome (RPTOR) cytoplasm (RPTOR)
RPTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 15 91.52 High High
antagonist 30 85.48 High High
opiate 27 85.04 High High
Opioid 15 79.24 Quite High
MU agonist 3 75.88 Quite High
palliative 6 69.68 Quite High
narcan 3 52.64 Quite High
Pain management 3 34.48 Quite Low
analgesia 6 32.32 Quite Low
Breakthrough pain 3 30.48 Quite Low
Disease Link Frequency Relevance Heat
Disease 6 74.16 Quite High
Cancer 18 70.80 Quite High
Appetite Loss 3 68.84 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 68.28 Quite High
Thrombocytopenia 3 67.72 Quite High
Hyperglycemia 3 67.00 Quite High
Anaemia 3 66.40 Quite High
Constipation 3 66.16 Quite High
Pressure And Volume Under Development 3 66.08 Quite High
Vomiting 3 65.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we demonstrate that methylnaltrexone (MNTX) acts synergistically with the mTOR inhibitors, rapamycin and temsirolimus, on inhibition of VEGF-induced angiogenic events.
Regulation (acts) of mTOR
1) Confidence 0.41 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.71 Pain Relevance 0.32
The substrate specificity of mTOR is regulated by complex formation with other proteins.
Regulation (regulated) of mTOR
2) Confidence 0.41 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.10
Temsirolimus and rapamycin inhibit the downstream target of activated Akt, mTOR Complex 1 [1,15,26].
Regulation (target) of mTOR
3) Confidence 0.21 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.67

General Comments

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