INT299349

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPTOR) lysosome (RPTOR) cytoplasm (RPTOR)
RPTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
Immobilon 10 96.60 Very High Very High Very High
antagonist 50 29.52 Quite Low
Opioid 25 29.08 Quite Low
opiate 45 5.00 Very Low Very Low Very Low
mu opioid receptor 25 5.00 Very Low Very Low Very Low
Morphine 15 5.00 Very Low Very Low Very Low
palliative 10 5.00 Very Low Very Low Very Low
analgesia 10 5.00 Very Low Very Low Very Low
narcan 5 5.00 Very Low Very Low Very Low
Pain management 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 30 5.00 Very Low Very Low Very Low
Renal Cancer 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Anaemia 5 5.00 Very Low Very Low Very Low
Thrombocytopenia 5 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 5 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 5.00 Very Low Very Low Very Low
Asthenia 5 5.00 Very Low Very Low Very Low
Mucositis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The siRNA for human mTOR, Src, Rictor, FKBP12 and Akt were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and were utilized according to the manufacturer's specifications.
Localization (utilized) of mTOR
1) Confidence 0.68 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.04
The samples were then immunoprecipitated with either anti-Raptor or anti-Rictor IgG followed by SDS-PAGE in 4-15% polyacrylamide gels, transfer onto Immobilon™ membranes, and developed with specific primary and secondary antibodies.
Localization (immunoprecipitated) of anti-Raptor associated with immobilon
2) Confidence 0.68 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.08
To further investigate the roles of MNTX and temsirolimus in VEGF-mediated Akt signaling, we examined two main mTOR-associated protein complexes, mTOR Complex 1, consisting of various proteins including mTOR, FKBP12 (a major target of mTOR inhibitors including temsirolimus) and Raptor, and mTOR Complex 2, consisting of various proteins including SIN1 and Rictor.
Localization (target) of mTOR
3) Confidence 0.68 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
The siRNA for human mTOR, Src, Rictor, FKBP12 and Akt were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and were utilized according to the manufacturer's specifications.
Localization (purchased) of mTOR
4) Confidence 0.68 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.04
To further investigate the roles of MNTX and temsirolimus in VEGF-mediated Akt signaling, we examined two main mTOR-associated protein complexes, mTOR Complex 1, consisting of various proteins including mTOR, FKBP12 (a major target of mTOR inhibitors including temsirolimus) and Raptor, and mTOR Complex 2, consisting of various proteins including SIN1 and Rictor.
Localization (target) of mTOR
5) Confidence 0.30 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0

General Comments

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