INT299350

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.26
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPTOR) lysosome (RPTOR) cytoplasm (RPTOR)
RPTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 18 71.76 Quite High
analgesia 12 69.88 Quite High
opiate 54 69.32 Quite High
palliative 12 67.16 Quite High
antagonist 60 64.76 Quite High
mu opioid receptor 30 64.08 Quite High
Breakthrough pain 6 51.00 Quite High
Pain management 6 48.92 Quite Low
Opioid 30 45.48 Quite Low
narcan 6 39.56 Quite Low
Disease Link Frequency Relevance Heat
Cancer 36 52.48 Quite High
Hyperinsulinism 6 51.76 Quite High
Pain 12 51.00 Quite High
Disease 12 28.80 Quite Low
Renal Cancer 12 24.00 Low Low
Anaemia 6 5.00 Very Low Very Low Very Low
Thrombocytopenia 6 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 6 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 5.00 Very Low Very Low Very Low
Asthenia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results (Figure 5-B) indicate that Src is required for both serine and threonine phosphorylation of Akt, the PI3 kinase pathway is required for threonine phosphorylation of Akt and mTOR Complex 2 is required for serine phosphorylation of Akt.
Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.75 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
Activated mTOR Complex 1 phosphorylates several target proteins including S6K and 4EBP1 involved in cell proliferation, growth and survival [1,2,4,5,26].
Phosphorylation (phosphorylates) of mTOR
2) Confidence 0.75 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.28
The mTOR Complex 2 serine phosphorylates Akt and is involved in actin cytoskeletal regulation [2,4,14,41,42].
Phosphorylation (phosphorylates) of mTOR
3) Confidence 0.74 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.05 Pain Relevance 0.48
We extended these finding by observing that Src regulates VEGF-induced, PI3 kinase and mTOR-dependent, serine/threonine phosphorylation of Akt important for EC proliferation and migration.
Phosphorylation (phosphorylation) of mTOR
4) Confidence 0.57 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.05 Pain Relevance 0
We extended these finding by observing that Src regulates VEGF-induced, PI3 kinase and mTOR-dependent, serine/threonine phosphorylation of Akt important for EC proliferation and migration.
Phosphorylation (phosphorylation) of mTOR
5) Confidence 0.57 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.05 Pain Relevance 0
Inhibition of tyrosine phosphatase activity (3,4-dephostatin) blocked the synergy between MNTX and temsirolimus and increased VEGF-induced tyrosine phosphorylation of Src with enhanced PI3 kinase and mTOR Complex 2-dependent phosphorylation of Akt and subsequent activation of mTOR Complex 1 (rapamycin and temsirolimus target), while silencing Src, Akt or mTOR complex 2 components blocked VEGF-induced angiogenic events.


Phosphorylation (phosphorylation) of mTOR
6) Confidence 0.57 Published 2010 Journal J Angiogenes Res Section Abstract Doc Link PMC2831839 Disease Relevance 0.10 Pain Relevance 0.06

General Comments

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