INT299365

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.91
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
spinal cord 2
eyes 1
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 170 100.00 Very High Very High Very High
Kinase C 22 98.88 Very High Very High Very High
ischemia 194 98.24 Very High Very High Very High
Pain 106 86.96 High High
Dorsal horn 10 59.52 Quite High
anesthesia 9 55.60 Quite High
Glutamate 6 48.80 Quite Low
Bile 2 47.72 Quite Low
Eae 17 47.28 Quite Low
Dorsal horn neuron 15 44.84 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 285 99.78 Very High Very High Very High
Apoptosis 23 99.34 Very High Very High Very High
Cv Unclassified Under Development 142 98.24 Very High Very High Very High
Stress 27 97.88 Very High Very High Very High
Disease 129 96.00 Very High Very High Very High
Hyperlipidemia 6 94.72 High High
Injury 52 88.04 High High
Pain 116 86.96 High High
Parkinson's Disease 30 85.80 High High
Neuroblastoma 2 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, relatively low levels of Mapk8 mRNA would be necessary to maintain the steady state levels of the protein.
Transcription (levels) of Mapk8
1) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.32 Pain Relevance 0.22
The low responding strains correctly partitioned together as more highly expressing Mapk8 mRNA, and there was a statistically significant difference in mRNA levels between the high and low responding strains.
Transcription (expressing) of Mapk8 associated with sprains and strains
2) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.92 Pain Relevance 0.19
Additional mRNA and protein analysis of Mapk8 in spinal cord tissue
Transcription (tissue) of Mapk8 in spinal cord associated with spinal cord
3) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.67 Pain Relevance 0.18
Additional mRNA and protein analysis of Mapk8 in spinal cord tissue
Transcription (analysis) of Mapk8 in spinal cord associated with spinal cord
4) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.67 Pain Relevance 0.18
However, as demonstrated by the negative correlation coefficient for the mRNA-behavior relationship in Table 2 and confirmatory data in Figure 3, the behaviorally higher responding strains had lower Mapk8 mRNA levels.
Transcription (levels) of Mapk8 associated with sprains and strains
5) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.39 Pain Relevance 0.33
ERK1/2, p38, JNK1/2/3, and c-jun mRNA and protein expression were studied using immunofluorescence staining, western blot analysis, and real-time PCR techniques.


Transcription (expression) of JNK1
6) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.83 Pain Relevance 0.25
It was also reported that oxidative stress induced by complex I inhibition biphasically activated the pro-apoptotic factor c-Jun-N-terminal kinase (JNK) and the transcription factor NF-?
Transcription (transcription) of JNK associated with stress and apoptosis
7) Confidence 0.16 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2947925 Disease Relevance 0.95 Pain Relevance 0
JNK1, JNK2, and JNK3 mRNA expressions in the neuroretina were slightly decreased after ischemia and 5 h of reperfusion but unchanged after ischemia and 12 or 20 h of reperfusion (Figure 12) compared to sham-operated eyes.


Transcription (expressions) of JNK1 in eyes associated with ischemia
8) Confidence 0.14 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.64 Pain Relevance 0.36
, PKB/AKT, ERK, and JNK, as well as the transcriptional activity of CREB.
Transcription (activity) of JNK
9) Confidence 0.12 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.53 Pain Relevance 0.05

General Comments

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