INT299366

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.29
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 34 98.68 Very High Very High Very High
Pain 21 74.40 Quite High
Glutamate 4 48.80 Quite Low
Dorsal horn 2 46.96 Quite Low
Dorsal horn neuron 3 32.28 Quite Low
cytokine 1 30.00 Quite Low
qutenza 2 15.28 Low Low
diabetic neuropathy 1 13.76 Low Low
Substantia nigra 7 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 9 100.00 Very High Very High Very High
Stress 5 99.08 Very High Very High Very High
Sprains And Strains 57 89.60 High High
Parkinson's Disease 29 88.20 High High
Neuroblastoma 1 87.72 High High
Pain 23 74.40 Quite High
Disease 29 70.76 Quite High
Syndrome 7 64.16 Quite High
Dementia 4 59.76 Quite High
Aging 39 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, relatively low levels of Mapk8 mRNA would be necessary to maintain the steady state levels of the protein.
Positive_regulation (necessary) of Transcription (levels) of Mapk8
1) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.32 Pain Relevance 0.22
It was also reported that oxidative stress induced by complex I inhibition biphasically activated the pro-apoptotic factor c-Jun-N-terminal kinase (JNK) and the transcription factor NF-?
Positive_regulation (activated) of Transcription (transcription) of JNK associated with stress and apoptosis
2) Confidence 0.11 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2947925 Disease Relevance 0.97 Pain Relevance 0

General Comments

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