INT299368

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mkks, Mapk8) cytosol (Mapk8) signal transduction (Mapk8)
mitochondrion (Mapk8) nucleus (Mapk8) cytoskeleton (Mkks)
Mkks (Mus musculus)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 34 60.84 Quite High
Eae 3 43.04 Quite Low
Pain 21 36.56 Quite Low
cOX1 2 35.28 Quite Low
COX2 1 32.96 Quite Low
Dorsal horn 2 9.12 Low Low
Neuropathic pain 3 5.00 Very Low Very Low Very Low
intrathecal 3 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 99.16 Very High Very High Very High
Sprains And Strains 57 69.16 Quite High
Inflammatory Pain 1 43.04 Quite Low
Pain 23 36.56 Quite Low
Nociception 6 31.52 Quite Low
Injury 2 7.12 Low Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Members of the MKKs (MAPK kinases) which activate JNK pathway are themselves under negative regulation by substrates of JNK, whilst MKPs (MAP kinase phosphatase) which inhibit the pathway are positively regulated by some of the same substrates [31,32].
MKKs Positive_regulation (activate) of JNK
1) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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