INT29938

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Context Info
Confidence 0.07
First Reported 1988
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.83
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
neurons 1
cerebrospinal fluid 1
ANTXRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 14 99.60 Very High Very High Very High
opioid receptor 10 98.54 Very High Very High Very High
antagonist 2 97.64 Very High Very High Very High
Central grey 6 96.68 Very High Very High Very High
substance P 5 95.68 Very High Very High Very High
Calcium channel 3 92.00 High High
agonist 15 91.60 High High
Cannabinoid 4 90.88 High High
conotoxin 2 90.60 High High
Opioid receptor 1 2 86.88 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 12 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 4 97.52 Very High Very High Very High
Urological Neuroanatomy 6 96.68 Very High Very High Very High
Neuroblastoma 2 94.60 High High
Cv Unclassified Under Development 1 35.84 Quite Low
Cv General 3 Under Development 1 30.96 Quite Low
Coronary Artery Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the opioid receptors were capable of inhibiting AC via Galpha(i1)CG and Galpha(i3)CG in pertussis toxin-treated cells, AC supersensitization induced by chronic opioid treatment remained sensitive to pertussis toxin.
Positive_regulation (sensitive) of pertussis toxin associated with bordatella infection, opioid receptor and opioid
1) Confidence 0.07 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11166929 Disease Relevance 0.44 Pain Relevance 0.52
Recently, alpha(2)-adrenoceptor activation was shown to play an important role in the vasoconstriction of normal coronary arteries, whereas in the presence of atherosclerosis, the activation of both alpha(1)- and alpha(2)-adrenoceptors reduces coronary blood flow in humans. alpha(2)-Adrenoceptors activate pertussis toxin (PTX)-sensitive G proteins, whereas alpha(1)-adrenoceptors couple to PTX-insensitive G proteins.
Positive_regulation (activate) of pertussis toxin in blood associated with bordatella infection and increased venous pressure under development
2) Confidence 0.03 Published 1999 Journal Circ. Res. Section Abstract Doc Link 10559144 Disease Relevance 0.37 Pain Relevance 0.06
The stimulation of 45Ca(2+)-uptake by DALN was resistant to pertussis toxin (PTX), suggesting that Gi/Go GTP-binding proteins did not mediate this effect.
Positive_regulation (resistant) of pertussis toxin associated with bordatella infection
3) Confidence 0.00 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12007836 Disease Relevance 0.27 Pain Relevance 0.38
Prolonged opioid treatment of HEK 293 cells expressing opioid receptors are known to induce adenylyl cyclase supersensitization, a process that requires pertussis toxin (PTX)-sensitive G(i/o) proteins.
Positive_regulation (requires) of pertussis toxin associated with bordatella infection, opioid receptor and opioid
4) Confidence 0.00 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043551 Disease Relevance 0.10 Pain Relevance 0.44
The inhibitory effect of DAMGO on HVA Ca2+ channels was prevented almost completely by the pretreatment of pertussis toxin (PTX) for 8-10 h, suggesting that DAMGO modulation on N-type Ca2+ channels in rat PAG neurons is mediated by PTX-sensitive G proteins.
Positive_regulation (pretreatment) of pertussis toxin in neurons associated with bordatella infection and central grey
5) Confidence 0.00 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9084607 Disease Relevance 0.46 Pain Relevance 0.57
We next examined the loss of responsiveness of both GTPase and adenylate cyclase in membranes prepared from cells that had been exposed to increasing concentrations of pertussis toxin (PTX) to inactivate PTX-sensitive G proteins in vivo.
Positive_regulation (increasing) of pertussis toxin associated with bordatella infection
6) Confidence 0.00 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2849042 Disease Relevance 0.10 Pain Relevance 0.41
To test for involvement of Gi/o proteins, pertussis toxin (PTX) was injected into the cerebrospinal fluid of newborn rats, and slices from these animals were tested 48 h later for block of drug effects on rhythm.
Positive_regulation (involvement) of pertussis toxin in cerebrospinal fluid associated with bordatella infection
7) Confidence 0.00 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8806921 Disease Relevance 0.10 Pain Relevance 0.48

General Comments

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