INT299403

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Star) cytosol (Star) transport (Star)
mitochondrion (Star)
Star (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cysts 36 97.20 Very High Very High Very High
Infertility 4 96.00 Very High Very High Very High
Adhesions 8 83.20 Quite High
Polycystic Ovary Syndrome 5 79.56 Quite High
Reprotox - General 1 22 73.28 Quite High
Repression 52 67.28 Quite High
Targeted Disruption 30 26.72 Quite Low
Precocious Puberty 38 24.80 Low Low
Syndrome 24 5.00 Very Low Very Low Very Low
Premature Ovarian Failure 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a strong genetic contribution to the phenotype in each case, but no mutations in the GNAS1, LHCGR, FSHR, StAR, NR5A1, DMRT4 and NOBOX were found, including DNA extracted from the ovarian cyst tissue in case 9.


Neg (no) Regulation (mutations) of StAR associated with ovarian cysts
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892512 Disease Relevance 0.63 Pain Relevance 0
This approach appears to have succeeded in that the mouse StAR gene was detected and had been previously demonstrated to be Foxl2 responsive in a human system [15].
Regulation (responsive) of StAR
2) Confidence 0.35 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.07 Pain Relevance 0
Our finding that the mouse StAR gene is a Foxl2 target validates the approach chosen for this study.
Regulation (target) of StAR
3) Confidence 0.21 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.08 Pain Relevance 0
The steroidogenic acute regulatory protein (StAR) gene that has been identified as Foxl2 responsive by others was identified in this study also, thereby supporting the effectiveness of our strategy.
Regulation (responsive) of steroidogenic acute regulatory protein
4) Confidence 0.21 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
The steroidogenic acute regulatory protein (StAR) gene that has been identified as Foxl2 responsive by others was identified in this study also, thereby supporting the effectiveness of our strategy.
Regulation (responsive) of StAR
5) Confidence 0.21 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

General Comments

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