INT299410

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) nucleus (Foxl2) DNA binding (Foxl2)
transcription factor binding (Foxl2)
Anatomy Link Frequency
ovary 1
Foxl2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 5 99.04 Very High Very High Very High
Repression 65 91.68 High High
Herpes Simplex Virus 10 88.76 High High
Targeted Disruption 35 81.28 Quite High
Adhesions 10 28.80 Quite Low
Rheumatoid Arthritis 5 21.40 Low Low
Syndrome 30 5.00 Very Low Very Low Very Low
Premature Ovarian Failure 25 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 10 5.00 Very Low Very Low Very Low
Blepharophimosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Foxl2 fusion protein derivatives
Positive_regulation (derivatives) of Foxl2
1) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.25 Pain Relevance 0
Sirt1 was also identified as a Foxl2 regulated gene that is activated by Foxl2 [18].
Positive_regulation (activated) of Foxl2
2) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.31 Pain Relevance 0
Therefore, Sirt1 induction could alter the activity of Foxl2-VP16, as well as repress other genes, resulting in down regulation of genes in Foxl2-VP16 transfected cells.
Positive_regulation (induction) of Foxl2-VP16
3) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.38 Pain Relevance 0
Cellular levels of Foxl2 were increased via transient co-transfection of KK1 cells using a Foxl2 expression vector and a GnRHR promoter-luciferase fusion reporter vector.
Positive_regulation (increased) of Foxl2
4) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
This analysis resulted in the discovery of 360 new genes of known function that were shared between the KK1 and mouse ovary studies increasing the total number of potential Foxl2 target genes to 996 (Additional file 4).
Positive_regulation (increasing) of Foxl2 in ovary
5) Confidence 0.38 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0

General Comments

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