INT299413

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 2.08
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) nucleus (Foxl2) DNA binding (Foxl2)
transcription factor binding (Foxl2)
Anatomy Link Frequency
pituitary 1
granulosa cell 1
ovary 1
Foxl2 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 13 73.76 Quite High
cytokine 13 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 13 99.36 Very High Very High Very High
Repression 169 97.92 Very High Very High Very High
Rheumatoid Arthritis 13 91.72 High High
Targeted Disruption 91 89.80 High High
Adhesions 26 82.60 Quite High
Syndrome 78 64.32 Quite High
Blepharophimosis 26 63.84 Quite High
Apoptosis 26 62.84 Quite High
Ocular Toxicity (including Many Sub-types) 26 62.48 Quite High
Premature Ovarian Failure 65 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sirt1 was also identified as a Foxl2 regulated gene that is activated by Foxl2 [18].
Regulation (regulated) of Foxl2
1) Confidence 0.58 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.30 Pain Relevance 0
The effect of Foxl2 mediated gene regulation was examined through the use of vectors expressing Foxl2 fusion proteins designed to either activate or repress gene expression (fusions are described in Methods section below).
Regulation (regulation) of Foxl2
2) Confidence 0.58 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.21 Pain Relevance 0
One group used the human KGN granulosa cell line and over-expression of FoxL2 to identify potential targets and qPCR to confirm numerous FoxL2 regulated genes [6].
Regulation (regulated) of FoxL2 in granulosa cell
3) Confidence 0.51 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
The repressor induction mechanism for VP16 repression is a distinct possibility in light of recent studies that have explored the mechanisms involved in the control of Foxl2 transactivation activity.
Regulation (control) of Foxl2 associated with repression
4) Confidence 0.43 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.25 Pain Relevance 0
The results of the pairwise analysis are summarized in the comprehensive listing of 636 potential targets of the Foxl2 transcription factor (Additional File 4).
Regulation (targets) of Foxl2
5) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.21 Pain Relevance 0
Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Background

Regulation (regulation) of Foxl2 in ovary
6) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Title Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
In addition, these investigators demonstrated that the Foxl2 promoter is repressed by Sirt1 expression as part of a feedback mechanism of regulation in response to stress [18].
Regulation (regulation) of Foxl2 promoter associated with stress
7) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.38 Pain Relevance 0
One identified target, the gonadotropin releasing hormone receptor (GnRHR) gene, was chosen for further study and validation of Foxl2 responsiveness.
Regulation (responsiveness) of Foxl2
8) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
The mechanism of Foxl2 regulation of this process has not been elucidated.
Regulation (regulation) of Foxl2
9) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
The GnRHR gene identified through microarray analysis has been validated as Foxl2 responsive through promoter cloning and reporter gene analysis.
Regulation (responsive) of Foxl2
10) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.45 Pain Relevance 0.04
The GnRHR gene was chosen based on the results of our previous study which implicated Foxl2 in the regulation of GnRHR in the pituitary derived ?
Regulation (implicated) of Foxl2 in pituitary
11) Confidence 0.22 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.05 Pain Relevance 0
The steroidogenic acute regulatory protein (StAR) gene that has been identified as Foxl2 responsive by others was identified in this study also, thereby supporting the effectiveness of our strategy.
Regulation (responsive) of Foxl2
12) Confidence 0.22 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Our finding that the mouse StAR gene is a Foxl2 target validates the approach chosen for this study.
Regulation (target) of Foxl2
13) Confidence 0.22 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox