INT299414

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Context Info
Confidence 0.74
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 29
Disease Relevance 4.86
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) nucleus (Foxl2) DNA binding (Foxl2)
transcription factor binding (Foxl2)
Anatomy Link Frequency
granulosa cell 7
eyelid 1
Foxl2 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 29 85.84 High High
cytokine 29 5.00 Very Low Very Low Very Low
Dopamine 29 5.00 Very Low Very Low Very Low
Inflammation 29 5.00 Very Low Very Low Very Low
Pain 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premature Ovarian Failure 145 99.58 Very High Very High Very High
Congenital Anomalies 29 99.42 Very High Very High Very High
Syndrome 174 98.62 Very High Very High Very High
Herpes Simplex Virus 58 95.16 Very High Very High Very High
Repression 377 93.96 High High
Ocular Toxicity (including Many Sub-types) 58 93.08 High High
Blepharophimosis 58 92.80 High High
Targeted Disruption 203 92.08 High High
Cytomegalovirus Infection 29 87.68 High High
Adhesions 58 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-transfection of Foxl2-Mad attenuated the ability of Foxl2-VP16 to activate luciferase expression by 95% (data not shown).
Gene_expression (transfection) of Foxl2
1) Confidence 0.74 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.24 Pain Relevance 0
One group used the human KGN granulosa cell line and over-expression of FoxL2 to identify potential targets and qPCR to confirm numerous FoxL2 regulated genes [6].
Gene_expression (over) of FoxL2 in granulosa cell
2) Confidence 0.74 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
The effect of Foxl2 mediated gene regulation was examined through the use of vectors expressing Foxl2 fusion proteins designed to either activate or repress gene expression (fusions are described in Methods section below).
Gene_expression (expressing) of Foxl2
3) Confidence 0.74 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.20 Pain Relevance 0
The first study involved over-expression of FoxL2 in the human KGN granulosa cell line and Nimblegen gene chips [6].
Gene_expression (over) of FoxL2 in granulosa cell
4) Confidence 0.74 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.30 Pain Relevance 0
However, due to endogenous expression of Foxl2 in KK1 cells, simple over-expression resulting from transfection of a Foxl2 expression vector may not affect levels of gene expression sufficiently to be detected efficiently by microarray analysis.
Gene_expression (expression) of Foxl2
5) Confidence 0.64 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.13 Pain Relevance 0
However, due to endogenous expression of Foxl2 in KK1 cells, simple over-expression resulting from transfection of a Foxl2 expression vector may not affect levels of gene expression sufficiently to be detected efficiently by microarray analysis.
Gene_expression (expression) of Foxl2
6) Confidence 0.64 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
Levels of gene expression were compared between mock transfected cells and those that were transfected with Foxl2-VP16 and Foxl2-MAD, respectively.
Gene_expression (transfected) of Foxl2
7) Confidence 0.64 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.25 Pain Relevance 0
Levels of gene expression were compared between mock transfected cells and those that were transfected with Foxl2-VP16 and Foxl2-MAD, respectively.
Gene_expression (transfected) of Foxl2-VP16
8) Confidence 0.64 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.25 Pain Relevance 0
g of Foxl2-VP16 expression vector in 30 ?
Gene_expression (expression) of Foxl2-VP16
9) Confidence 0.64 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.15 Pain Relevance 0
Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Background

Gene_expression (expression) of Foxl2 in granulosa cell
10) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Title Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
The effect of Foxl2 over-expression on the activity of the GnRHR promoter was determined by comparing the luciferase activity of the promoter in the presence of pFoxl2 (over-expression) to the activity of the promoter in the absence of Foxl2 over-expression (pcDNA 3.1).
Gene_expression (expression) of Foxl2
11) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.05 Pain Relevance 0
The effect of Foxl2 over-expression on the activity of the GnRHR promoter was determined by comparing the luciferase activity of the promoter in the presence of pFoxl2 (over-expression) to the activity of the promoter in the absence of Foxl2 over-expression (pcDNA 3.1).
Gene_expression (over) of Foxl2
12) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.06 Pain Relevance 0
The results of these analyses indicate that over-expression of Foxl2 resulted in a significant increase in GnRHR promoter activity.
Gene_expression (expression) of Foxl2
13) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Transient transfection analyses were carried out to study the effect of Foxl2 over-expression on GnRHR gene promoter-luciferase fusion activity.
Gene_expression (over) of Foxl2
14) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
One group used the human KGN granulosa cell line and over-expression of FoxL2 to identify potential targets and qPCR to confirm numerous FoxL2 regulated genes [6].
Gene_expression (expression) of FoxL2 in granulosa cell
15) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
Foxl2 over-expression activated the GnRHR promoter 5.8 fold (Figure 2).


Gene_expression (expression) of Foxl2
16) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.05 Pain Relevance 0
Type I BPES is characterized by eyelid malformation and POF suggesting that the expression of FoxL2 is critical in the developing eyelid as well as in the maintenance of ovarian function.
Gene_expression (expression) of FoxL2 in eyelid associated with congenital anomalies, syndrome and premature ovarian failure
17) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 1.01 Pain Relevance 0
Foxl2 over-expression activated the GnRHR promoter 5.8 fold (Figure 2).


Gene_expression (over) of Foxl2
18) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.05 Pain Relevance 0
The first study involved over-expression of FoxL2 in the human KGN granulosa cell line and Nimblegen gene chips [6].
Gene_expression (expression) of FoxL2 in granulosa cell
19) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.30 Pain Relevance 0
The effect of Foxl2 over-expression on the activity of the GnRHR promoter was determined by comparing the luciferase activity of the promoter in the presence of pFoxl2 (over-expression) to the activity of the promoter in the absence of Foxl2 over-expression (pcDNA 3.1).
Gene_expression (expression) of Foxl2
20) Confidence 0.57 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.06 Pain Relevance 0

General Comments

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