INT299416

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.72
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Star) cytosol (Star) transport (Star)
mitochondrion (Star)
Anatomy Link Frequency
granulosa cells 1
Star (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 5 100.00 Very High Very High Very High
Dopamine 5 10.56 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 30 99.92 Very High Very High Very High
Blepharophimosis 10 99.68 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 10 99.00 Very High Very High Very High
Premature Ovarian Failure 25 97.52 Very High Very High Very High
Adhesions 10 83.20 Quite High
Repression 65 72.08 Quite High
Ectodermal Dysplasia 5 69.12 Quite High
Necrosis 5 60.76 Quite High
Cancer 10 60.40 Quite High
Targeted Disruption 35 37.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two genes involved in metabolism, StAR and Vldlr, are expressed in granulosa cells and the gene products of both are involved in steroidogenesis.
Gene_expression (expressed) of StAR in granulosa cells
1) Confidence 0.53 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.26 Pain Relevance 0
Our finding that the mouse StAR gene is a Foxl2 target validates the approach chosen for this study.
Gene_expression (target) of StAR
2) Confidence 0.53 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.08 Pain Relevance 0
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Gene_expression (cAMP) of StAR associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
3) Confidence 0.53 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.65 Pain Relevance 0.05
This approach appears to have succeeded in that the mouse StAR gene was detected and had been previously demonstrated to be Foxl2 responsive in a human system [15].
Gene_expression (detected) of StAR
4) Confidence 0.47 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.06 Pain Relevance 0
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Gene_expression (cAMP) of steroidogenic acute regulatory protein associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
5) Confidence 0.46 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.66 Pain Relevance 0.05

General Comments

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