INT299419

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Ctla4) plasma membrane (Ctla4)
Anatomy Link Frequency
T cell 2
Ctla4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 87.12 High High
Dopamine 1 65.12 Quite High
Inflammation 30 60.28 Quite High
agonist 10 5.00 Very Low Very Low Very Low
complementary and alternative medicine 10 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 91.68 High High
Cancer 10 73.28 Quite High
Necrosis 2 72.80 Quite High
Eosinophilia 3 67.00 Quite High
Asthma 104 63.96 Quite High
INFLAMMATION 31 60.28 Quite High
Chronic Disease 1 58.92 Quite High
Ectodermal Dysplasia 1 57.92 Quite High
Syndrome 9 55.12 Quite High
General Immunology 14 52.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional regulation of Ctla4 by Foxl2 in granulosa cells may be the result of similarities in the Forkhead binding sequence elements in the Ctla4 promoter that allow both factors to regulate the gene, with cell type determining the presence of either FoxP3 or Foxl2 in T cells or granulosa cells respectively.
Transcription (Transcriptional) of Ctla4 in T cells
1) Confidence 0.43 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.35 Pain Relevance 0.03
Outcome measures included T cell proliferation and IL-4, IL-5, and IL-13 secretion (assessed by [3H]-thymidine incorporation and ELISA, respectively) and characterization of the induced Treg by qRT-PCR for FoxP3, LAG3, CTLA4, and IL-10 mRNA expression.
Transcription (expression) of CTLA4 in T cell
2) Confidence 0.13 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.36 Pain Relevance 0.14

General Comments

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