INT299425

Context Info Confidence 0.36 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.92 Pain Relevance 0.04

aging (Sin3a) nucleus (Sin3a) DNA binding (Sin3a) protein complex (Sin3a) transcription factor binding (Sin3a)

Sin3a (Mus musculus)

Pain Link Frequency Relevance Heat adenocard 1 86.80 imagery 6 5.00 cytokine 1 5.00 fibrosis 1 5.00 anesthesia 1 5.00 Inflammation 1 5.00 Pain 1 5.00 Dopamine 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Repression 14 99.96 Premature Ovarian Failure 5 94.76 Syndrome 6 93.48 Ocular Toxicity (including Many Sub-types) 2 92.32 Blepharophimosis 2 92.04 Embryonic Lethality 2 73.08 Targeted Disruption 14 70.88 Cancer 4 61.04 Stress 4 5.00 Necrosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-galactosidase; DMEM: Dulbecco's Modified Eagle's Medium; F12: Ham's F12 nutrient mixture; FBS: fetal bovine serum; SID: mSin3 interaction domain; ?

Sin3 Binding (interaction) of

1) Confidence 0.36 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.62 Pain Relevance 0.04

Our in vitro studies, however, revealed that Smyd2 acts as a transcriptional repressor when bound to HDAC1 and the Sin3 repression complex [20].

Sin3 Binding (bound) of associated with repression

2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.30 Pain Relevance 0

General Comments

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