INT299449

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) nuclear envelope (Tpr) nucleus (Foxl2)
molecular_function (Tpr) DNA binding (Foxl2) transcription factor binding (Foxl2)
Anatomy Link Frequency
pituitary 1
granulosa cell 1
Foxl2 (Mus musculus)
Tpr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 52 99.70 Very High Very High Very High
Herpes Simplex Virus 8 89.88 High High
Adhesions 8 68.52 Quite High
Rheumatoid Arthritis 4 46.00 Quite Low
Syndrome 24 39.36 Quite Low
Ectodermal Dysplasia 4 38.88 Quite Low
Cytomegalovirus Infection 4 34.24 Quite Low
Necrosis 4 30.52 Quite Low
Cancer 8 30.16 Quite Low
Targeted Disruption 28 12.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous study had demonstrated that Foxl2 could potentially regulate the GnRHR promoter in pituitary derived ?
Foxl2 Regulation (regulate) of promoter in pituitary
1) Confidence 0.00 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Transient co-transfection studies to determine the Foxl2 regulation of the GnRHr promoter were carried out using KK1 cells transfected with various combinations of luciferase reporter vectors and pcDNA 3.1 expression vectors.
Foxl2 Spec (determine) Regulation (regulation) of promoter
2) Confidence 0.00 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.07 Pain Relevance 0
These Foxl2 fusion proteins can be used as tools for gene discovery as the DNA binding domain of Foxl2 will guide either the activation or repression domain to the promoter regions of genes that are normally regulated by Foxl2 via specific DNA binding.
Foxl2 Regulation (regulated) of promoter associated with repression
3) Confidence 0.00 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.19 Pain Relevance 0
Second, we have demonstrated the GnRHR gene promoter is regulated in a positive manner by the transcription factor Foxl2 in the KK1 granulosa cell line.
factor Foxl2 Regulation (regulated) of promoter in granulosa cell
4) Confidence 0.00 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

General Comments

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