INT299450

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) Golgi apparatus (Ctla4) plasma membrane (Ctla4)
nucleus (Foxl2) DNA binding (Foxl2) transcription factor binding (Foxl2)
Anatomy Link Frequency
T cells 1
Foxl2 (Mus musculus)
Ctla4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1 64.48 Quite High
cytokine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 7 91.04 High High
Cancer 2 74.00 Quite High
Necrosis 1 73.52 Quite High
Ectodermal Dysplasia 1 58.64 Quite High
Syndrome 6 55.84 Quite High
Apoptosis 2 46.72 Quite Low
Repression 13 5.00 Very Low Very Low Very Low
Premature Ovarian Failure 5 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional regulation of Ctla4 by Foxl2 in granulosa cells may be the result of similarities in the Forkhead binding sequence elements in the Ctla4 promoter that allow both factors to regulate the gene, with cell type determining the presence of either FoxP3 or Foxl2 in T cells or granulosa cells respectively.
Foxl2 Regulation (regulation) of Ctla4 in T cells
1) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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