INT299454

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) signal transduction (Gnrhr) plasma membrane (Gnrhr)
nucleus (Foxl2) DNA binding (Foxl2) transcription factor binding (Foxl2)
Anatomy Link Frequency
granulosa cell 3
Foxl2 (Mus musculus)
Gnrhr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 12 49.88 Quite Low
Ectodermal Dysplasia 2 49.40 Quite Low
Necrosis 2 41.04 Quite Low
Cancer 4 40.68 Quite Low
Targeted Disruption 14 17.40 Low Low
Repression 26 5.00 Very Low Very Low Very Low
Premature Ovarian Failure 10 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 4 5.00 Very Low Very Low Very Low
Blepharophimosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Background

Gene_expression (expression) of Foxl2 in granulosa cell Positive_regulation (leads) of Positive_regulation (activation) of gonadotropin releasing hormone receptor in granulosa cell
1) Confidence 0.42 Published 2010 Journal J Ovarian Res Section Title Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Foxl2 over-expression resulted in a 6 fold activation of the GnRHR gene promoter in transient co-transfections of KK1 cells.
Gene_expression (expression) of Foxl2 Positive_regulation (resulted) of Positive_regulation (activation) of GnRHR
2) Confidence 0.36 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

General Comments

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