INT299457

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) signal transduction (Gnrhr) plasma membrane (Gnrhr)
nucleus (Foxl2) DNA binding (Foxl2) transcription factor binding (Foxl2)
Anatomy Link Frequency
granulosa cell 1
ovary 1
Foxl2 (Mus musculus)
Gnrhr (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 2 91.76 High High
cytokine 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 12 82.32 Quite High
Blepharophimosis 4 81.84 Quite High
Ocular Toxicity (including Many Sub-types) 4 80.48 Quite High
Premature Ovarian Failure 10 77.52 Quite High
Repression 26 77.48 Quite High
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient co-transfections of a GnRHR-luciferase reporter vector and a wild-type Foxl2 expression vector provided evidence of Foxl2 transcriptional activation of the GnRHR gene promoter in the mouse ovary derived KK1 granulosa cell line.


Foxl2 Positive_regulation (activation) of GnRHR in granulosa cell
1) Confidence 0.42 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.56 Pain Relevance 0.05
The Foxl2 responsiveness of the GnRHR gene has been validated and provided evidence of Foxl2 transcriptional activation of the GnRHR gene promoter in the mouse ovary derived KK1 granulosa cell line.



Foxl2 Positive_regulation (activation) of GnRHR in ovary
2) Confidence 0.42 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

General Comments

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