INT299458

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1, Foxl2) nucleus (Sirt1, Foxl2) nucleoplasm (Sirt1)
nuclear envelope (Sirt1) histone binding (Sirt1) DNA binding (Foxl2)
Sirt1 (Mus musculus)
Foxl2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 97.52 Very High Very High Very High
Repression 13 82.92 Quite High
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Premature Ovarian Failure 5 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low
Blepharophimosis 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, these investigators demonstrated that the Foxl2 promoter is repressed by Sirt1 expression as part of a feedback mechanism of regulation in response to stress [18].
Gene_expression (expression) of Sirt1 Negative_regulation (repressed) of Foxl2 promoter associated with stress
1) Confidence 0.25 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.

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