INT299461

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) signal transduction (Gnrhr) plasma membrane (Gnrhr)
nucleus (Foxl2) DNA binding (Foxl2) transcription factor binding (Foxl2)
Anatomy Link Frequency
pituitary 2
granulosa cell 1
ovary 1
Foxl2 (Mus musculus)
Gnrhr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7 5.00 Very Low Very Low Very Low
Dopamine 7 5.00 Very Low Very Low Very Low
adenocard 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 14 68.52 Quite High
Targeted Disruption 49 54.16 Quite High
Syndrome 42 43.44 Quite Low
Ectodermal Dysplasia 7 42.96 Quite Low
Repression 91 34.88 Quite Low
Necrosis 7 34.60 Quite Low
Cancer 14 34.24 Quite Low
Apoptosis 14 27.20 Quite Low
Reprotox - General 1 7 19.48 Low Low
Premature Ovarian Failure 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous study had demonstrated that Foxl2 could potentially regulate the GnRHR promoter in pituitary derived ?
Foxl2 Regulation (regulate) of GnRHR in pituitary
1) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
This was the first demonstration of Foxl2 regulation of the GnRHR gene in ovarian derived cells.
Foxl2 Regulation (regulation) of GnRHR
2) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Transient co-transfection studies to determine the Foxl2 regulation of the GnRHr promoter were carried out using KK1 cells transfected with various combinations of luciferase reporter vectors and pcDNA 3.1 expression vectors.
Foxl2 Spec (determine) Regulation (regulation) of GnRHr
3) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.07 Pain Relevance 0
Therefore, these transfection data validate the microarray data which suggest that Foxl2 regulates GnRHR and demonstrate that Foxl2 acts as an activator of the GnRHR gene.


Foxl2 Regulation (regulates) of GnRHR
4) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Second, we have demonstrated the GnRHR gene promoter is regulated in a positive manner by the transcription factor Foxl2 in the KK1 granulosa cell line.
factor Foxl2 Regulation (regulated) of GnRHR in granulosa cell
5) Confidence 0.21 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
The Foxl2 responsiveness of the GnRHR gene has been validated and provided evidence of Foxl2 transcriptional activation of the GnRHR gene promoter in the mouse ovary derived KK1 granulosa cell line.



Foxl2 Regulation (responsiveness) of GnRHR in ovary
6) Confidence 0.21 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
The GnRHR gene was chosen based on the results of our previous study which implicated Foxl2 in the regulation of GnRHR in the pituitary derived ?
Foxl2 Regulation (regulation) of GnRHR in pituitary
7) Confidence 0.21 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.05 Pain Relevance 0

General Comments

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