INT29956

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.81
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dsp) protein binding, bridging (Dsp)
Anatomy Link Frequency
filaments 2
hypothalamus 1
41-2 1
Dsp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 6 98.86 Very High Very High Very High
Pain 17 95.40 Very High Very High Very High
Clonidine 1 91.84 High High
Stimulus evoked pain 1 90.16 High High
noradrenaline 4 87.68 High High
Serotonin 1 86.96 High High
Neuropathic pain 20 79.36 Quite High
monoamine 2 75.00 Quite High
Central nervous system 6 73.32 Quite High
unmyelinated 4 67.12 Quite High
Disease Link Frequency Relevance Heat
Neuropathy 10 100.00 Very High Very High Very High
Disease 7 99.58 Very High Very High Very High
Adhesions 22 96.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 109 96.24 Very High Very High Very High
Pain 12 90.16 High High
Congenital Anomalies 4 87.32 High High
Neuropathic Pain 34 79.36 Quite High
Poisoning 3 75.64 Quite High
Infection 4 51.68 Quite High
Apoptosis 9 27.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sensitivity to alpha 2-agents, methoxamine, and clenbuterol was respectively slightly increased or unchanged, decreased, and clearly increased after DSP-4.
Positive_regulation (increased) of DSP-4
1) Confidence 0.41 Published 1988 Journal Sleep Section Abstract Doc Link 2849796 Disease Relevance 0 Pain Relevance 0.13
Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4.
Positive_regulation (increased) of DSP-4 in hypothalamus associated with hippocampus
2) Confidence 0.40 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 7505893 Disease Relevance 0 Pain Relevance 0.55
RESULTS: During the two recall periods, there was a significant increase in ibuprofen DSP calls to the poisons information centre (RR, 1.86; 95% Cl, 1.41-2.44; P = 0.001).
Positive_regulation (increase) of DSP in 41-2
3) Confidence 0.40 Published 2002 Journal Med. J. Aust. Section Body Doc Link 11913916 Disease Relevance 0.08 Pain Relevance 0
Therefore, desmoplakin is required for the docking and integration of the intermediate filament system with the desmosomal cadherins, either through direct physical interaction or as part of a complex through interaction with the armadillo proteins, PG and PKP2.
Positive_regulation (required) of desmoplakin in filament
4) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0
Insertion of the intermediate filaments into the desmosomal complex requires desmoplakin (DP), a plaque protein that binds to intermediate filaments and to desmosomal proteins such as PKP2, PG, desmocollin, and desmoglein.
Positive_regulation (requires) of desmoplakin in filaments
5) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.10 Pain Relevance 0
Firstly, a disease-related DSP associated with advanced disease and secondly a drug-induced DSP associated with the use of nucleoside reverse transcriptase inhibitors as part of an anti-retroviral therapy (Martin et al., 2003; Marshall et al., 2005).
Positive_regulation (induced) of DSP associated with neuropathy and disease
6) Confidence 0.08 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.64 Pain Relevance 0.30

General Comments

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