INT299626

Context Info Confidence 0.02 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0

extracellular space (IGF1, IGFBP3, IGF1) extracellular region (IGF1, IGFBP3, IGF1) signal transduction (IGF1, IGF1) nucleus (IGFBP3)

IGF1 (Homo sapiens) IGFBP3 (Homo sapiens) IGF1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 17.96 Inflammation 12 17.56 imagery 22 5.00 positron emission tomography 6 5.00 Spinal cord 3 5.00 Action potential 2 5.00 depression 1 5.00 adenocard 1 5.00 Pain 1 5.00 Neurotransmitter 1 5.00

Disease Link Frequency Relevance Heat Hypoglycemia 1 98.28 Frailty 35 85.52 Reprotox - General 1 1 65.32 INFLAMMATION 12 17.56 Endometriosis (extended) 1 7.80 Aging 13 5.00 Injury 8 5.00 Obesity 7 5.00 Mobility Limitation 5 5.00 Insulin Resistance 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By complexing IGF-1 to its primary circulating binding protein IGFBP-3, it is possible to significantly increase the IGF-1 dose while eliminating the side effect of hypoglycemia that occurs with IGF-1 alone [101].

IGF-1 Binding (complexing) of protein IGFBP-3 Spec (possible) Positive_regulation (increase) of IGF-1 associated with hypoglycemia

1) Confidence 0.02 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.39 Pain Relevance 0

General Comments

This test has worked.