INT29964

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.56
Pain Relevance 11.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
liver 2
neurons 2
spinal cord 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 100 100.00 Very High Very High Very High
Dynorphin 19 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
Dopamine 116 99.50 Very High Very High Very High
Pain 1 98.88 Very High Very High Very High
Endogenous opioid 9 97.28 Very High Very High Very High
Opioid 28 97.12 Very High Very High Very High
Kappa opioid receptor 2 96.48 Very High Very High Very High
Analgesic 1 94.44 High High
fortral 2 81.12 Quite High
Disease Link Frequency Relevance Heat
Pain 1 98.88 Very High Very High Very High
Fever 8 96.72 Very High Very High Very High
Schizophrenia 5 93.12 High High
Mental Disorders 1 82.48 Quite High
Stress 2 80.56 Quite High
Pheochromocytoma 6 75.00 Quite High
Apoptosis 10 54.12 Quite High
Death 9 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As previous studies have shown enhancement of DA neurotransmission often results in elevated dynorphin and DRD1 mRNA levels in direct striatal projecting neurons, the unbalance between the direct and indirect striatal projection pathways observed in Pten KO animals could be explained by subtle but long-term changes in DA dynamics.
Positive_regulation (results) of Positive_regulation (elevated) of dynorphin in neurons associated with dopamine and dynorphin
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.11 Pain Relevance 0.55
These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.
Positive_regulation (indicate) of Positive_regulation (co-existence) of Met-enkephalin-Arg-Gly-Leu associated with enkephalin and opioid
2) Confidence 0.49 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6495993 Disease Relevance 0.07 Pain Relevance 2.32
These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.
Positive_regulation (indicate) of Positive_regulation (co-existence) of Leu-enkephalin associated with enkephalin and opioid
3) Confidence 0.49 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6495993 Disease Relevance 0.07 Pain Relevance 2.32
These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.
Positive_regulation (indicate) of Positive_regulation (co-existence) of Leu-enkephalin associated with enkephalin and opioid
4) Confidence 0.49 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6495993 Disease Relevance 0.07 Pain Relevance 2.32
However, we observed a significant interactive effect with the receptor 3 of dopamine gene (DRD3); in particular, the frequency of subjects carrying PDYN allele 3 being also homozygotes for DRD3 Gly allele (of Ser9Gly polymorphism) was significantly greater in patients than controls.
Positive_regulation (carrying) of Positive_regulation (homozygotes) of PDYN associated with dopamine
5) Confidence 0.49 Published 2002 Journal Neuropsychobiology Section Abstract Doc Link 12207142 Disease Relevance 0.50 Pain Relevance 0.28
It is concluded that some parameter(s) of the pregnant condition triggers the activation of a spinal cord dynorphin system that attenuates the pain associated with late pregnancy and labor.
Positive_regulation (triggers) of Positive_regulation (activation) of dynorphin in spinal cord associated with pain, dynorphin and spinal cord
6) Confidence 0.25 Published 1993 Journal Brain Res. Section Abstract Doc Link 8106119 Disease Relevance 0.10 Pain Relevance 1.01
Of the three anion transport systems (iodide, hippurate and liver-like) present in the choroid plexus, only the liver-like transport system seems to be important to central inactivation of beta-endorphin, D-ala2-Met-enkephalin and D-ala2-Leu-enkephalin since iodipamide (an inhibitor of the liver-like transport system) augmented the hyperthermia.
Positive_regulation (important) of Positive_regulation (inactivation) of Leu-enkephalin in liver associated with enkephalin and fever
7) Confidence 0.05 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6877539 Disease Relevance 0.47 Pain Relevance 1.06
Not only does mRNA for the endogenous opioid dynorphin coexist in the same cells as vasopressin but we have now been able to demonstrate that stimuli to vasopressin secretion also result in a markedly increased accumulation of dynorphin mRNA.
Positive_regulation (increased) of Positive_regulation (accumulation) of dynorphin mRNA associated with dynorphin and endogenous opioid
8) Confidence 0.00 Published 1988 Journal J. Exp. Biol. Section Abstract Doc Link 2850337 Disease Relevance 0.08 Pain Relevance 0.72
Not only does mRNA for the endogenous opioid dynorphin coexist in the same cells as vasopressin but we have now been able to demonstrate that stimuli to vasopressin secretion also result in a markedly increased accumulation of dynorphin mRNA.
Positive_regulation (result) of Positive_regulation (accumulation) of dynorphin mRNA associated with dynorphin and endogenous opioid
9) Confidence 0.00 Published 1988 Journal J. Exp. Biol. Section Abstract Doc Link 2850337 Disease Relevance 0.08 Pain Relevance 0.72

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